多模态MRI在职业性锰暴露神经毒性中的研究进展OA

Chronic manganese exposure can adversely affect the central nervous system,resulting in motor and cognitive impairments.Advances in neuroimaging have enabled multimodal MRI to sensitively and non-invasively characterize structural,functional,and metabolic brain alterations in manganese-exposed individuals,even at early and subclinical stages.These imaging findings provide critical insights into the neurobiological mechanisms underlying manganese-induced neurotoxicity.This review synthesizes current evidence on the application of multiple MRI modalities in occupational manganese exposure,focusing on their ability to detect microstructural damage,functional network alterations,and potential imaging biomarkers.It also summarizes the current limitations of these studies and outlines future research directions,aiming to support mechanistic interpretation,early identification of manganese-related neural injury,and improved imaging-based risk assessment in occupational settings.