抑郁症伴失眠的多模态磁共振成像研究进展OA

Depression is a common mental disorder that imposes a substantial burden on individuals and society.Insomnia is one of the most prevalent and clinically persistent symptoms in depression and shows a close bidirectional relationship with its onset,progression,and outcome,often indicating greater symptom severity,poorer treatment response,and a higher risk of relapse.Accumulating evidence suggests that depression and insomnia may,at least in part,share overlapping neurobiological mechanisms.In recent years,the application of multimodal MRI has substantially advanced the investigation of the neural underpinnings of depression comorbid with insomnia.This review systematically summarizes recent findings from structural MRI(sMRI),diffusion tensor imaging(DTI),functional MRI(fMRI),arterial spin labeling(ASL),and magnetic resonance spectroscopy(MRS)studies in this field.We highlight converging evidence of alterations in gray matter structure,white matter microstructure,glymphatic system function,brain activity,functional connectivity,and neurochemical profiles in individuals with depression and comorbid insomnia.In addition,we discuss the limitations of the existing literature and outline directions for future research,with the goal of facilitating the identification of imaging-based biomarkers and informing precision medicine approaches in clinical practice.