中药靶向调控抗氧化酶治疗血管性痴呆的研究进展OA

Vascular dementia(VaD)refers to cognitive dysfunction syndrome caused by cerebrovascular lesions.In recent years,with the intensification of aging process,the prevalence of the disease has been rising.How to effectively prevent and treat the disease has become a hot spot in the academic community.Compared with traditional Western medicine treatment,traditional Chinese medicine has the characteristics of multi-target synergy,safety and effectiveness.At present,there are many studies in this field such as superoxide dismutase(SOD),catalase(CAT),and glutathione peroxidase(GPxs).Targeted antioxidant enzymes can exert neuroprotective effects on VaD by improving oxidative stress,inhibiting inflammatory responses,protecting the blood-brain barrier,regulating neuronal autophagy,and inhibiting apoptosis.Based on this,this study takes TCM monomers and compounds as the starting points to review the clinical application progress of flavonoids,extracts,terpenes,polysaccharides,phenols,saponins,stasis-reducing agents,orifice-opening agents,and tonic agents in the treatment of VaD.The aim is to lay a theoretical foundation for subsequent exploration of its pathogenesis and in-depth study of the prevention and treatment of VaD in traditional Chinese medicine,and to provide new ideas for the research and development of new drugs.