基于"肾亏毒滞"与氧化应激相关性探讨狼疮性肾炎中医辨治OA

Oxidative stress refers to the process in which the imbalance between oxidative and antioxidant systems leads to damage caused by the accumulation of reactive oxygen species within cells.Lupus nephritis(LN)pathogenesis is associated with oxidative stress.Based on the theory"kidney deficiency and toxin stagnation",the key pathogenesis for treatment based on syndrome differentiation of LN is"kidney deficiency harboring toxins,toxins damaging kidney meridian".Its fundamental cause is the loss of kidney yin and latent toxins,the pathological reason is toxin accumulation with excessive heat and blood stasis obstructing kidney collaterals,and the root of the critical condition is deficiency caused by damage,leading to dual deficiency of yin and yang.The staged treatment targeting oxidative stress as an intervention point has been proposed,including the latent phase requiring pathogen elimination and source interception to resist oxidative stress and regulate immunity,the onset phase requiring immediate disease prevention and transformation to clear pathological products and suppress damage,and the exacerbation phase requiring both attack and tonify to improve the microenvironment and restore homeostasis.Specific treatment methods and prescription of medications require comprehensive assessment of the underlying mechanisms and evidence-based formulation.