雄激素受体在三阴性乳腺癌中的表达与病理特征相关性研究OA
Study on the correlation between androgen receptor expression and pathological characteristics in triple-negative breast cancer
目的 研究雄激素受体(androgen receptor,AR)在三阴性乳腺癌组织中的表达及其临床意义.方法 选取201 8 年 1 月至2025 年3 月在淄博市中心医院手术的320 例三阴性乳腺癌患者,采用免疫组织化学法对AR等生物标志物进行检测,AR阳性阈值定义为≥1%的核染色阳性.结果 AR阳性率为47.81%(153/320),AR表达与年龄、p63、Ki-67、HER-2 显著相关(P＜0.001),与肿瘤大小、淋巴结转移、CK5/6、脉管浸润、TIL无显著相关性.结论 AR表达与患者年龄较大、p63 阳性、HER-2 低表达、Ki-67 低增殖相关,且与p63、HER-2 表达呈正相关,在三阴性乳腺癌发生发展过程中起重要作用.因此,AR有望成为三阴性乳腺癌基因治疗的新靶点.
Objective To investigate the expression of androgen receptor(AR)in triple-negative breast cancer tissues and explore its clinical significance.Methods This study included 320 patients with triple-negative breast cancer who underwent sur-gery at Zibo Central Hospital from January 201 8 to March 2025.Immunohistochemistry was used to detect the expression of AR and other biomarkers.The AR positivity threshold was defined as≥1%nuclear staining.Results The AR positivity rate was 47.81%(153/320).The AR expression was significantly associated with age,p63,Ki-67,and HER-2(P＜0.001),but not significantly correlated with tumor size,lymph node metastasis,CK5/6,vascular/lymphatic invasion,or tumor-infiltrating lym-phocytes(TIL).Conclusion The AR expression is correlated with older age,p63 positivity,low HER-2 expression,and low Ki-67 proliferation.It shows positive correlations with p63 and HER-2 expression,indicating a significant role in the development of triple-negative breast cancer.Therefore,AR holds promise as a novel therapeutic target for triple-negative breast cancer.
刘源;翟怡
山东医药大学第二临床医学院 山东 烟台 264003淄博市中心医院肿瘤内科 山东 淄博 255000
医药卫生
三阴性乳腺癌雄激素受体靶向治疗
triple-negative breast cancerandrogen receptortargeted therapy
《滨州医学院学报》 2026 (2)
153-158,6
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