辅助生殖人群体脂率和体骨骼肌率与抑郁的相关性研究OA
Correlational research on body fat rate and skeletal muscle rate with depression in the population of assisted reproduction
目的:探讨辅助生殖人群体脂率和体骨骼肌率与抑郁的关系.方法:采用便利抽样法选取2022年7-10月在安徽医科大学附属第一医院生殖医学中心行辅助生殖技术治疗的不孕不育患者885例,采用患者健康问卷9项抑郁量表(patient health questionnaire-9,PHQ-9)调查患者抑郁情况,采用生物电阻抗(bioelectrical impedance analysis,BIA)原理的InBody仪测量人群体脂率以及体骨骼肌率的数据,使用多元线性回归、广义线性模型、趋势化检验探讨体脂率、体骨骼肌率与抑郁的关联,采用限制性立方样条分析其剂量-反应关系.结果:辅助生殖人群的抑郁检出率为52.0％,体脂率平均值为28.01％,体骨骼肌率平均值为39.73％.控制混杂因素后,体脂率与抑郁呈正相关(β=0.07,95％CI:0.01,0.14),体骨骼肌率与抑郁呈负相关(β=-0.12,95％CI:-0.24,-0.01),且在男性、年龄＞30岁的辅助生殖人群中相关性有统计学意义(P＜0.05).辅助生殖人群的体脂率、体骨骼肌率与抑郁存在显著线性关联(Pnon-linear＞0.05).结论:辅助生殖人群的体脂率、体骨骼肌率与抑郁风险存在关联,采取相应的运动和饮食等干预以控制体重、减少体脂肪、增加骨骼肌,可望降低辅助生殖人群的抑郁发生率.
Objective:To investigate the relationship between body fat rates and skeletal muscle rates with depression among patients undergoing assisted reproductive technology(ART)treatments.Methods:A total of 885 infertility patients who underwent ART treatment at the Center for Reproductive Medicine of the First Affiliated Hospital of Anhui Medical University from July to October,2022 were se-lected using the convenience sampling method.The basic information of the patients was investigated,depression was investigated using the patient health questionnaire-9(PHQ-9),and human adiposity and body skeletal muscle rate data were measured using the InBody instrument with the principle of bioelectri-cal impedance analysis(BIA).Multiple linear regression,generalized linear model,and trend test were used to investigate the association between adiposity,skeletal muscle mass,and depression in the assisted reproduction population,as well as the dose-response relationship using restricted cubic spline(RCS)analysis.Results:The mean detection rate of depression in the ART population was 52.0％,with 55.5％in women and 45.5％in men.The average body fat rate was 28.01％,and the average body skeletal muscle rate was 39.73％.After correcting for confounders,the body fat rate was observed to be positive-ly associated with depression(β=0.07,95％CI:0.01,0.14),and the body skeletal muscle rate was negatively associated with depression(β=-0.12,95％CI:-0.24,-0.01).Trend-based tests showed a highly significant monotonically increasing trend in depression with the increasing body fat rate and the decreasing body skeletal muscle rate.These associations were significant(P＜0.05)in the male population and in the assisted reproduction population aged＞30 years.No significant non-linear associa-tions were found between the body fat rate,the skeletal muscle rate and depression in the overall ART-treated population(Pnon-linear＞0.05).Conclusion:The patients undergoing ART have a higher rate of depression detection,and their body fat and skeletal muscle rates are associated with the risk of depres-sion in ART patients.Interventions,such as weight control,body fat reduction,and an exercise diet that increases skeletal muscle and other body components are expected to reduce the incidence of depression in assisted reproduction.
宋晓欢;罗桂英;王婕妤;贾月迪;江飞;朱梦黎;王丹妮
安徽医科大学公共卫生学院健康促进与行为科学系,合肥 230032安徽医科大学附属第一医院生殖医学中心,合肥 230000安徽医科大学附属第一医院生殖医学中心,合肥 230000安徽医科大学公共卫生学院健康促进与行为科学系,合肥 230032安徽医科大学公共卫生学院营养与食品卫生学系,合肥 230032安徽医科大学公共卫生学院营养与食品卫生学系,合肥 230032安徽医科大学公共卫生学院健康促进与行为科学系,合肥 230032
医药卫生
辅助生殖脂肪抑郁骨骼肌限制性立方样条
Assisted reproductionFatDepressionSkeletal muscleRestricted cubic spline
《北京大学学报（医学版）》 2026 (2)
319-326,8
国家自然科学基金青年项目(72004001)、安徽省高校科研人文项目(2022AH050627)Supported by the Youth Program of the Na-tional Natural Science Foundation of China(72004001)and the Anhui University Scientific Research Humanities Project(2022AH050627)
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