长链脂肪酸通过抑制髓源抑制性细胞延缓肿瘤进展OA

To clarify the regulatory role and underlying mechanism of long-chain fatty acids(LCFAs)in the tumor immune microenvironment,this study focused on myeloid-derived suppressor cells(MDSCs)and various mouse tumor models.By employing in vitro and in vivo LCFA exposure and high-LCFA diet interventions,we analyzed the effects of LCFAs on the immunosuppressive function of MDSCs,CD8+T cell-mediated anti-tumor immunity,and tumor progression.The results demonstrated that treating cells with LCFAs both in vitro and in vivo significantly decreased the expression levels of characteristic immunosuppressive genes in monocytic MDSCs(M-MDSCs)and polymorphonuclear MDSCs(PMN-MDSCs).Animal experiments showed that mice fed a high-LCFA diet exhibited delayed tumor progression and prolonged survival across different cancer models.Furthermore,this LCFA-mediated inhibition of M-MDSCs and PMN-MDSCs correlates with enhanced CD8+T antitumor immunity,which is abolished in tumor-bearing nude mice.These results reveals a previously under-recognized role of LCFAs in the tumor immune microenvironment,implicating novel therapeutic strategies for cancer treatment.