基于五行圆运动理论探讨绝经后骨质疏松症OA

This paper addresses postmenopausal osteoporosis(PMOP),a major global public health challenge associated with high fracture risk and a substantial disease and socioeconomic burden.Current mainstream treatments,primarily based on anti-resorptive drugs,face limitations regarding long-term safety,patient adherence,and the improvement of bone microarchitecture quality.While traditional Chinese medicine(TCM)syndrome differentiation and treatment offer advantages in holistic regulation,its approach often focuses on static deficiencies of the liver,spleen,and kidney,lacking a systematic theoretical framework to explain the dynamic progression of the disease.Therefore,this study introduces the five-elements circular motion theory to construct a dynamic pathogenesis model and a staged treatment system aligned with the natural course of PMOP.By establishing a physiological circular motion model with the kidney as the root,spleen as the axis,and liver as the pivot,the study proposes that the core pathogenesis of PMOP lies in the dynamic interplay and vicious cycle of"kidney deficiency as the root cause,pivot-axis dysfunction,and loss of ascending and descending order".The pathological evolution begins with kidney essence depletion,then progresses along the sequence of circular motion to affect the liver and spleen,ultimately leading to dysfunction of the heart and lungs and disruption of Qi circulation.Based on this,the therapeutic principle of"regulating the pivot,activating the central axis,and replenishing the root"is established,along with a dynamic three-stage treatment strategy:nourishing the kidney and soothing the liver in the early stage;strengthening the spleen and kidney,resolving phlegm and unblocking collaterals in the intermediate stage;and harmonizing yin-yang and linking the heart and kidney in the advanced stage.This theoretical framework,centered on"restoring circular motion",provides a systematic and novel pathway for TCM prevention and treatment of PMOP that deeply interconnects with the disease's progression.