Exploring microorganism-host interactions:Emerging organoid models and analytical approachesOA
Microorganisms play a vital role in human health through their interactions with the body.Studies of host-microbe mechanisms and interactions are crucial for advancing health management.Recently,the organoid-based models have provided new platforms in this field.Derived from human tissues,these models offer several advantages over traditional systems and,when combined with advanced analytical techniques,they enable deeper insights into host-microbe interactions.In this review,we summarize the different models and techniques used,with a particular focus on the newly developed organoid models.We discuss how these models can be effectively utilized in microorganism-host interaction studies and address their associated limitations.
Yue Shi;Min Xu;Yanhong Huang;Jing Qu;Shumin Liao;Yingzi Liu;Liang Li
Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases,Department of Pharmacology,School of Medicine,Southern University of Science and Technology,Shenzhen,ChinaJoint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases,Department of Pharmacology,School of Medicine,Southern University of Science and Technology,Shenzhen,ChinaJoint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases,Department of Pharmacology,School of Medicine,Southern University of Science and Technology,Shenzhen,ChinaDepartment of Pathogen Biology,Shenzhen Center for Disease Control and Prevention,Shenzhen,ChinaJoint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases,Department of Pharmacology,School of Medicine,Southern University of Science and Technology,Shenzhen,ChinaIntervention and Cell Therapy Center,Peking University Shenzhen Hospital,Shenzhen,ChinaJoint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases,Department of Pharmacology,School of Medicine,Southern University of Science and Technology,Shenzhen,China
医药卫生
disease modelinghost-microbe interactioninfectious diseasesorganoidsorgan-on-a-chip
《mLife》 2026 (1)
P.17-34,18
supported by the National Key Research and Development Program of China(2022YFC2304400 and 2022YFC2304401)the Shenzhen Medical Research Fund(D2401023)the National Natural Science Foundation of China(Grant No.82200034)the Natural Science Foundation of Shenzhen(JCYJ20240813115821029)the Sanming Project of Medicine in Shenzhen(SZSM202211035)the Shenzhen Key Medical Discipline(SZXK078)the SUSTech Starting-up Research Grant(Y01416133).
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