Mitochondrial Dysfunction as a Pathophysiological Bridge between Metabolic Dysfunction-Associated Fatty Liver Disease and Chronic Kidney DiseaseOA
Metabolic dysfunction-associated fatty liver disease(MAFLD)and chronic kidney disease(CKD)have shown a marked global increase in prevalence,placing a substantial burden on public health and healthcare systems worldwide.Epidemiological data demonstrate a significant overlap between these two conditions,with further evidence from research identifying common pathophysiological features,such as lipid metabolism dysregulation,disrupted energy balance,and chronic systemic inflammation.Mitochondria are central to the pathophysiology of both diseases.In addition to their role in energy production,mitochondria are involved in numerous critical cellular processes,including biosynthesis,lipid metabolism,oxidative phosphorylation,signal transduction,and apoptosis regulation.Mitochondrial dysfunction,characterized by increased reactive oxygen species,impaired adenosine triphosphate synthesis,disrupted mitophagy,and changes in mitochondrial morphology,is implicated in the progression of both MAFLDandCKD.Given the pivotal role of mitochondria in maintaining cellularmetabolism homeostasis,dysfunction of this organelle is increasingly recognized as a key mechanistic link that connects the pathophysiological processes underlying both MAFLD and CKD.This review underscores mitochondrial dysfunction as a pathogenic nexus between MAFLD and CKD and examines the mechanisms that drive their pathogenesis.
Congwei You;Anwen Yin;Jia Xia;Le Zhang;Xiaolei Wang;Yutong Hou
Department of Pediatrics,The Affiliated Wuxi People’s Hospital of Nanjing Medical University,Wuxi People’s Hospital,Wuxi Medical Center,Nanjing Medical University,Wuxi,214023,ChinaDepartment of Cardiology,The Affiliated Wuxi People’s Hospital of Nanjing Medical University,Wuxi People’s Hospital,Wuxi Medical Center,Nanjing Medical University,Wuxi,214023,ChinaDepartment of Nephrology,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,200127,ChinaDepartment of Pediatric Laboratory,Affiliated Children’s Hospital of Jiangnan University,Wuxi Children’s Hospital,Wuxi,214023,ChinaDepartment of Pediatrics,The Affiliated Wuxi People’s Hospital of Nanjing Medical University,Wuxi People’s Hospital,Wuxi Medical Center,Nanjing Medical University,Wuxi,214023,ChinaDepartment of Pediatric Laboratory,Affiliated Children’s Hospital of Jiangnan University,Wuxi Children’s Hospital,Wuxi,214023,China
医药卫生
Mitochondrial dysfunctionoxidative stresslipid metabolismmetabolic dysfunction-associated fatty liver disease(MAFLD)chronic kidney disease(CKD)liver-kidney crosstalk
《BIOCELL》 2026 (3)
P.24-46,23
supported by Top Talent Support Program for young and middle-aged people of Wuxi Health Committee(Grant No.HB2023008)Top Medical Expert Team of Wuxi Taihu Talent Plan(Grant Nos.DJTD202106,GDTD202105 and YXTD202101)Medical Key Discipline Program ofWuxi Health.Commission(Grant Nos.ZDXK2021007 and CXTD2021005)Top Talent Support Program for Young and Middle-Aged People of Wuxi Health Committee(Grant No.BJ2023090)Scientific Research Program of Wuxi Health Commission(Grant Nos.Z20210 and M202208).
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