Advances in the study of senegenin in vascular cognitive impairmentOA
Vascular cognitive impairment(VCI)denotes a condition marked by parenchymal brain damage resulting from vascular issues,ultimately culminating in cognitive deterioration that spans from mild cognitive impairment to vascular dementia.Senegenin is a saponin extract obtained from Polygala tenuifolia,a traditional Chinese medicinal herb known for its significant neuroprotective properties.The review analyzes the impact of senegenin on VCI from the viewpoints of traditional Chinese medicine(TCM)and contemporary medical practices.From the standpoint of TCM,we examine three notable traditional Chinese medicine formulations:Kaixin San,Dingzhi Xiaowan,and Smart Soup.We extensively examine the neuroprotective effects,antioxidant capabilities,and anti-inflammatory actions of senegenin from a contemporary medical standpoint.Additionally,we perform a retrospective review of the extraction and formulation techniques of senegenin.The aim of this review is to summarize the particular mechanisms of senegenin’s multi-targeting and to offer novel insights into clinical therapy strategies for VCI.
Yu-Tao Lu;Yuan-Yuan Xiang;Zi-Xuan Wang;Tian-Rui Yu;Ling He;Xian-Ming Cao;Xiao-Ping Yin;Zhi-Ying Chen
Department of Neurology,Affiliated Hospital of Jiujiang University,Jiujiang 332000,China Jiujiang Clinical Precision Medicine Research Center,Jiujiang 332000,ChinaJiujiang Clinical Precision Medicine Research Center,Jiujiang 332000,ChinaDepartment of Neurology,Affiliated Hospital of Jiujiang University,Jiujiang 332000,China Jiujiang Clinical Precision Medicine Research Center,Jiujiang 332000,ChinaDepartment of Neurology,Affiliated Hospital of Jiujiang University,Jiujiang 332000,China Jiujiang Clinical Precision Medicine Research Center,Jiujiang 332000,ChinaDepartment of Neurology,Affiliated Hospital of Jiujiang University,Jiujiang 332000,China Jiujiang Clinical Precision Medicine Research Center,Jiujiang 332000,ChinaDepartment of Neurology,Affiliated Hospital of Jiujiang University,Jiujiang 332000,China Jiujiang Clinical Precision Medicine Research Center,Jiujiang 332000,ChinaDepartment of Neurology,Affiliated Hospital of Jiujiang University,Jiujiang 332000,China Jiujiang Clinical Precision Medicine Research Center,Jiujiang 332000,ChinaDepartment of Neurology,Affiliated Hospital of Jiujiang University,Jiujiang 332000,China Jiujiang Clinical Precision Medicine Research Center,Jiujiang 332000,China Jiangxi Provincial Key Laboratory of Cell Precision Therapy,School of Basic Medical Sciences,Jiujiang University,Jiujiang,332005,Jiangxi,China
医药卫生
Senegeninvascular cognitive impairmentvascular dementiaPolygala tenuifoliatraditional Chinese medicinemodern medicine
《Traditional Medicine Research》 2026 (7)
P.49-59,11
the National Natural Science Foundation of China(81960221 to XPY,82260249 to XPY)Jiangxi Provincial Health Commission Science and Technology Plan project(202311506 to ZYC)Jiangxi Provincial Administration of Traditional Chinese Medicine science and technology plan project(2022A322 to ZYC)Youth Foundation of Natural Science Foundation of Jiangxi Province(20224BAB216045 to ZYC,20212BAB216069 to LH)Research and Reform Project on Education and Teaching in Ordinary Colleges and Universities of Jiangxi Province(JXJG-24-17-20 to ZYC,JXJG-24-17-2 to MQZ,JXYJG-2024-140 to XPY).
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