Hematological and neurological expressed 1-mediated anoikis resistance promotes anaplastic thyroid cancer metastasisOA
The plasticity of cancer cells enables them to adapt to selective pressures,further enhancing their survival advantage and resistance to apoptosis.Cancer cell plasticity operates through multiple mechanisms.Among them,the key to successful cancer metastasis mainly depends on epithelial-mesenchymal transition(EMT)and anoikis resistance.
Huangcan Li;Simiao Fan;Zhongqin Gong;Chunlei Nie;Jiangqi Liu;Lingbin Xue;Xianhai Zeng;Jason Ying Kuen Chan;Michael Chi Fai Tong;George Gong Chen
Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target&Clinical Pharmacology,The NMPA and State Key Laboratory of Respiratory Disease,School of Pharmaceutical Sciences,Guangzhou Medical University,Guangzhou,Guangdong 511436,China Department of Otorhinolaryngology,Head and Neck Surgery,Faculty of Medicine,Chinese University of Hong Kong,Hong Kong,China CUHK-Shenzhen Otolaryngology and Head and Neck Institute,Shenzhen Research Institute(SZRI),Shenzhen,Guangdong 518057,ChinaDepartment of Otorhinolaryngology,Head and Neck Surgery,Faculty of Medicine,Chinese University of Hong Kong,Hong Kong,ChinaDepartment of Otorhinolaryngology,Head and Neck Surgery,Faculty of Medicine,Chinese University of Hong Kong,Hong Kong,China CUHK-Shenzhen Otolaryngology and Head and Neck Institute,Shenzhen Research Institute(SZRI),Shenzhen,Guangdong 518057,ChinaDepartment of Head and Neck Surgery,Harbin Medical University Cancer Hospital,Harbin,Heilongjiang 150081,ChinaDepartment of Otolaryngology,Longgang E.N.T Hospital and Shenzhen Key Laboratory of E.N.T,Institute of E.N.T Shenzhen,Shenzhen,Guangdong 518116,ChinaDepartment of Otolaryngology,Longgang E.N.T Hospital and Shenzhen Key Laboratory of E.N.T,Institute of E.N.T Shenzhen,Shenzhen,Guangdong 518116,ChinaDepartment of Otolaryngology,Longgang E.N.T Hospital and Shenzhen Key Laboratory of E.N.T,Institute of E.N.T Shenzhen,Shenzhen,Guangdong 518116,ChinaDepartment of Otorhinolaryngology,Head and Neck Surgery,Faculty of Medicine,Chinese University of Hong Kong,Hong Kong,China CUHK-Shenzhen Otolaryngology and Head and Neck Institute,Shenzhen Research Institute(SZRI),Shenzhen,Guangdong 518057,ChinaDepartment of Otorhinolaryngology,Head and Neck Surgery,Faculty of Medicine,Chinese University of Hong Kong,Hong Kong,China CUHK-Shenzhen Otolaryngology and Head and Neck Institute,Shenzhen Research Institute(SZRI),Shenzhen,Guangdong 518057,ChinaDepartment of Otorhinolaryngology,Head and Neck Surgery,Faculty of Medicine,Chinese University of Hong Kong,Hong Kong,China CUHK-Shenzhen Otolaryngology and Head and Neck Institute,Shenzhen Research Institute(SZRI),Shenzhen,Guangdong 518057,China
医药卫生
expressed mediatedanaplastic thyroid cancer metastasisanoikis resistancecancer cellsapoptosiscancer cell plasticityneurologicalhematologicaladapt selective pressuresfurther
《Genes & Diseases》 2026 (2)
P.13-16,4
supported by grants from the Research Grants Council of the Hong Kong Special Administrative Region,China(No.CUHK 14108921)the National Natural Science Foundation of China(No.82402076).
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