m^(6)A modification erased by ALKBH5 promotes tumor growth and metastasis via regulation of YAP/ZEB1 axis in NSCLCOA
Early detection and effective treatment,as well as prevention of recurrence and metastasis,are crucial for patients with non-small cell lung cancer(NSCLC).1 Recent studies have shown that alkylation repair homolog 5(ALKBH5)reverses m^(6)A RNA methylation.
Dan Jin;Weihua Di;Rui Li;Shuang Shao;Jiwei Guo
Medical Research Center,Binzhou Medical University Hospital,Binzhou,Shandong 256603,ChinaDepartment of Pain,Binzhou Medical University Hospital,Binzhou,Shandong 256603,ChinaMedical Research Center,Binzhou Medical University Hospital,Binzhou,Shandong 256603,China Gastroenterology Department,Binzhou Medical University Hospital,Binzhou,Shandong 256603,ChinaMedical Research Center,Binzhou Medical University Hospital,Binzhou,Shandong 256603,ChinaMedical Research Center,Binzhou Medical University Hospital,Binzhou,Shandong 256603,China Gastroenterology Department,Binzhou Medical University Hospital,Binzhou,Shandong 256603,China
医药卫生
alkylation repair homologZEBrna methylationYAPNSCLCtumor growthALKBHm methylation
《Genes & Diseases》 2026 (2)
P.21-24,4
approved by the Ethics Committee of Binzhou Medical University Hospital,Shandong,China(No.2018-019-04).
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