Deficiency of TMEM16F in hair cells prevents diabetes-related and noise-induced hearing lossOA
Hearing loss is a common health condition associated with genetic variations, diseases, loud noise exposure, and aging. Diabetes mellitus, one of the most prevalent chronic diseases, is known to increase the incidence of hearing loss in humans. However, no effective therapeutics have been developed to treat diabetes-related hearing loss (DRHL). The most evident histopathologic characteristic in the cochleae of diabetic patients is degeneration of the stria vascularis and cochlear outer hair cells (OHCs).1 For noise-induced hearing loss (NIHL), damage to hair cells is also a principal cause.2 Therefore, promoting hair cell survival would be critical for preventing DRHL and NIHL.
Liyuan Chen;Na Wang;Jiajia Li;Yan Li;Li Yi;Yupeng Ling;Qiuling Zhao;Yibing Fang;Guilan Chen;Bo Zeng
Key Laboratory of Medical Electrophysiology,Ministry of Education&Medical Electrophysiological Key Laboratory of Sichuan Province,Institute of Cardiovascular Research,Southwest Medical University,Luzhou,Sichuan 646000,ChinaKey Laboratory of Medical Electrophysiology,Ministry of Education&Medical Electrophysiological Key Laboratory of Sichuan Province,Institute of Cardiovascular Research,Southwest Medical University,Luzhou,Sichuan 646000,ChinaKey Laboratory of Medical Electrophysiology,Ministry of Education&Medical Electrophysiological Key Laboratory of Sichuan Province,Institute of Cardiovascular Research,Southwest Medical University,Luzhou,Sichuan 646000,ChinaKey Laboratory of Medical Electrophysiology,Ministry of Education&Medical Electrophysiological Key Laboratory of Sichuan Province,Institute of Cardiovascular Research,Southwest Medical University,Luzhou,Sichuan 646000,ChinaKey Laboratory of Medical Electrophysiology,Ministry of Education&Medical Electrophysiological Key Laboratory of Sichuan Province,Institute of Cardiovascular Research,Southwest Medical University,Luzhou,Sichuan 646000,ChinaKey Laboratory of Medical Electrophysiology,Ministry of Education&Medical Electrophysiological Key Laboratory of Sichuan Province,Institute of Cardiovascular Research,Southwest Medical University,Luzhou,Sichuan 646000,ChinaInstitute of Pathology and Southwest Cancer Center,Southwest Hospital,Third Military Medical University(Army Medical University),and Key Laboratory of Tumor Immunopathology,Ministry of Education of China,Chongqing 400038,ChinaCardiac Surgery,Southwest Hospital,Third Military Medical University(Army Medical University),Chongqing 400038,ChinaKey Laboratory of Medical Electrophysiology,Ministry of Education&Medical Electrophysiological Key Laboratory of Sichuan Province,Institute of Cardiovascular Research,Southwest Medical University,Luzhou,Sichuan 646000,China School of Life and Health Sciences,Hainan Province Key Laboratory of One Health,Collaborative Innovation Center of Life and Health,Hainan University,Haikou,Hainan 570228,ChinaKey Laboratory of Medical Electrophysiology,Ministry of Education&Medical Electrophysiological Key Laboratory of Sichuan Province,Institute of Cardiovascular Research,Southwest Medical University,Luzhou,Sichuan 646000,China School of Life and Health Sciences,Hainan Province Key Laboratory of One Health,Collaborative Innovation Center of Life and Health,Hainan University,Haikou,Hainan 570228,China
医药卫生
cochlear outer hair cellsdegeneration stria vascularisTmem fdeficiencychronic diseasesdiabetes mellitushistopathologic characteristichair cells
《Genes & Diseases》 2026 (2)
P.78-81,4
supported by the National Natural Science Foundation of China(No.32171106)the Sichuan Science and Technology Program(China)(No.2022YFS0607,2022YFS0627)the Joint Research Program of Luzhou City and Southwest Medical University(Sichuan,China)(No.2020LZXNYDJ21)the Science and Technology Program of Luzhou City,Sichuan,China(No.2024JYJ043).
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