Current Insights Into Individualized Diagnosis and Treatment of Allergic Rhinitis Based on Phenotype and EndotypeOA
Allergic rhinitis(AR)is a chronic inflammatory disease of the nasal mucosa characterized by allergen sensitization and the involvement of multiple inflammatory mediators.Currently,the treatment of AR mainly includes symptomatic relief,anti-inflammatory therapy,and nerve desensitization.However,these treatments have limitations in fully integrating the underlying mechanisms with the clinical manifestations of AR.This review aims to summarize recent research findings on AR phenotypes and endotypes,enhance understanding of endotype-phenotype associations,and outline various treatment options based on phenotypes and endotypes to provide insights for early recognition and personalized clinical management of patients with AR.
Yue Gu;Long-Lan Shu;Tao Lu;Da-Yu Guan;Bo-Wen Zheng;Pan-Hui Xiong;Yang Shen;Yu-Cheng Yang
Department of Otorhinolaryngology,Upper Airway Inflammation and Tumor Laboratory,The First Affiliated Hospital of Chongqing Medical University,Chongqing,ChinaDepartment of Otorhinolaryngology,Upper Airway Inflammation and Tumor Laboratory,The First Affiliated Hospital of Chongqing Medical University,Chongqing,ChinaDepartment of Otorhinolaryngology,Upper Airway Inflammation and Tumor Laboratory,The First Affiliated Hospital of Chongqing Medical University,Chongqing,ChinaDepartment of Otorhinolaryngology,Upper Airway Inflammation and Tumor Laboratory,The First Affiliated Hospital of Chongqing Medical University,Chongqing,ChinaDepartment of Otorhinolaryngology,Upper Airway Inflammation and Tumor Laboratory,The First Affiliated Hospital of Chongqing Medical University,Chongqing,ChinaDepartment of Otorhinolaryngology,Upper Airway Inflammation and Tumor Laboratory,The First Affiliated Hospital of Chongqing Medical University,Chongqing,ChinaDepartment of Otorhinolaryngology,Upper Airway Inflammation and Tumor Laboratory,The First Affiliated Hospital of Chongqing Medical University,Chongqing,ChinaDepartment of Otorhinolaryngology,Upper Airway Inflammation and Tumor Laboratory,The First Affiliated Hospital of Chongqing Medical University,Chongqing,China
医药卫生
allergic rhinitisclinical treatmentendotypephenotype
《World Journal of Otorhinolaryngology-Head and Neck Surgery》 2026 (1)
P.124-135,12
grants from the National Natural Science Foundation of China(grant number 82471131)the Natural Science Foundation of Chongqing,China(grant numbers CSTB2023NSCQ-MSX0358 and CSTB2024NSCQ-MSX0642)the Chongqing Medical Scientific Research Project(Joint Project of Chongqing Health Commission and Science and Technology Bureau)(grant numbers 2023GDRC003 and 2024DBXM007)。
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