Severe nausea and vomiting after teprotumumab initiation with corticosteroid pretreatment:a case reportOA
Dear Editor,We present a case of severe weight loss from intractable nausea and vomiting after teprotumumab infusions pretreated with corticosteroids.Teprotumumab,a monoclonal antibody against insulin-like growth factor 1 receptor(IGF1-R),was approved in 2020 as the first and only approved medication for thyroid eye disease(TED)in the USA[1].The main reported adverse effects are muscle spasms,rare hearing loss,and transient hyperglycemia[1].PubMed search in August 2024 using search terms,“Teprotumumab”,“Weight Loss”,“Nausea”,and“Vomiting”revealed no similar reports.
Justin Youn;Kim Firn;Eman Hawy;Douglas Van Putten
Loma Linda University School of Medicine,11175 Campus St,Loma Linda,CA 92350,USALoma Linda University Eye Institute,11370 Anderson St#1800,Loma Linda,CA 92354,USALoma Linda University Eye Institute,11370 Anderson St#1800,Loma Linda,CA 92354,USALoma Linda University Eye Institute,11370 Anderson St#1800,Loma Linda,CA 92354,USA
医药卫生
nauseamuscle spasmsraresevere weight lossvomitingthyroid eye disease tedmonoclonal antibodyweight lossteprotumumab
《International Journal of Ophthalmology(English edition)》 2026 (4)
P.830-832,3
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