Photocatalyzed chemodivergent aerobic oxidation of naturally occurring Viridicatin and derivativesOA
A chemodivergent reaction is an appealing way to construct molecules with enriched structure diversity in a controlled manner. A plethora of methodologies were developed based on this concept, and transition metal-catalysis plays a central role among others catalysis systems own to its longstanding history. While a chemodivergent reaction based on organo-catalysis, especially photocatalysis, is rather limited as these concepts were only prevalent in the last two decades. With the ever-increasing importance of photocatalysis, a chemodivergent reaction based on such an activation pathway would be a meaningful direction. Herein, an efficient chemodivergent strategy for visible light photocatalysis is developed. By employing commercially available Rose Bengal as a photocatalyst, naturally occurring Viridicatin and its derivatives can be transformed into three different types of products through switchable single electron transfer (SET) or energy transfer (EnT) processes. Mechanistic studies have revealed that the oxygen as a reactive center, rather than carbon, is favored, which accounts for the first example of a C–O homo-dimerization product.
Yingxian Li;Hui Wang;Xuemin Jia;Bing Guo;Yuanyong Yang;Lei Tang;Zhiyong Jiang
School of Pharmacy,Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D,Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases,Guizhou Medical University,Guiyang 550014,China MOE Key Laboratory of Bioinorganic and Synthetic Chemistry,Sun Yat-Sen University,Guangzhou 510275,ChinaSchool of Pharmacy,Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D,Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases,Guizhou Medical University,Guiyang 550014,ChinaSchool of Pharmacy,Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D,Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases,Guizhou Medical University,Guiyang 550014,ChinaSchool of Pharmacy,Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D,Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases,Guizhou Medical University,Guiyang 550014,ChinaSchool of Pharmacy,Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D,Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases,Guizhou Medical University,Guiyang 550014,ChinaSchool of Pharmacy,Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D,Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases,Guizhou Medical University,Guiyang 550014,ChinaKey Laboratory of Natural Medicine and Immuno-Engineering,Henan University,Kaifeng 475004,China School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang 453007,China
化学化工
PhotocatalysisSingle electron transferEnergy transferChemodivergenceOxidation
《Green Synthesis and Catalysis》 2026 (1)
P.62-68,7
the National Natural Science Foundation of China(No.22061012)the Excellent Young Talents Plan of Guizhou Medical University(No.[2023]105)the GMU Training Program of the National Natural Science Foundation of China(No.22NSFCP13)the support from National-Local Joint Engineering Research Center for Innovative&Generic Chemical Drug&Guizhou Province Innovation Base of Common Major Chronic Disease Pathogenesis and Drug Development and Application(No.[2021]4029).
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