Mild and green thioacylation with dithiocarboxylates via photoredox catalysisOA
A photocatalysis process-enabled thioacylation of amines has been developed with eco-friendly feedstock potassium dithiocarboxylates as green thioacyl sources and water as the reaction solvent.The key to the success of this transformation is the light-induced generation of active dithioacyl disulfides as thioacyl donors.This green methodology has been successfully employed for the late-stage thioacylation of various amino compounds including drugs,hormones,amino acids and peptides under mild conditions.
Wen-Chao Gao;Wei Li;Juan Zhang;Hong-Hong Chang;Rong Zhou
College of Biomedical Engineering,Taiyuan University of Technology,Taiyuan 030024,ChinaCollege of Biomedical Engineering,Taiyuan University of Technology,Taiyuan 030024,ChinaCollege of Biomedical Engineering,Taiyuan University of Technology,Taiyuan 030024,ChinaCollege of Biomedical Engineering,Taiyuan University of Technology,Taiyuan 030024,ChinaCollege of Biomedical Engineering,Taiyuan University of Technology,Taiyuan 030024,China
化学化工
ThioamideThioacylationPhotoredox catalysisLate-stage modificationDithiocarboxylates
《Green Synthesis and Catalysis》 2026 (1)
P.69-74,6
supported by the National Natural Science Foundation of China(No.21901179)the Natural Science Foundation of Shanxi Province(No.202103021224067)the Scientific Activities of Selected Returned Overseas Professionals of Shanxi Province(No.20200002).
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