Palladium-catalyzed chemoselective synthesis of arylamines from cyclohexanones with ammonium saltsOA
The primary objective of organic synthesis is the utilization of inexpensive and readily available industrial chemicals in large quantities to produce valuable organic compounds.This study introduces a direct and selective approach for synthesizing arylamines using readily available cyclohexanones and ammonium salts through a dehydrogenative process.A variety of arylamine structural motifs,such as N-cyclohexylanilines,diphenylamines,and N-cyclohexyl-N-phenylanilines,were successfully synthesized with moderate to high yields.In comparison to traditional methods,these approaches are characterized by the utilization of simple starting materials,efficiency in steps and atom usage,as well as high selectivity.
Feng Zhao;Bin Tan;Wenlong Zhou;Qing Li;Jie Zhou;Yanting Wen;Guo-Jun Deng
Key Laboratory for Synthetic Biology of Traditional Chinese Medicine of Hunan Province,School of Pharmaceutical Sciences,Hunan University of Medicine,Huaihua 418000,ChinaKey Laboratory for Synthetic Biology of Traditional Chinese Medicine of Hunan Province,School of Pharmaceutical Sciences,Hunan University of Medicine,Huaihua 418000,ChinaKey Laboratory for Synthetic Biology of Traditional Chinese Medicine of Hunan Province,School of Pharmaceutical Sciences,Hunan University of Medicine,Huaihua 418000,ChinaKey Laboratory for Synthetic Biology of Traditional Chinese Medicine of Hunan Province,School of Pharmaceutical Sciences,Hunan University of Medicine,Huaihua 418000,ChinaKey Laboratory for Synthetic Biology of Traditional Chinese Medicine of Hunan Province,School of Pharmaceutical Sciences,Hunan University of Medicine,Huaihua 418000,ChinaKey Laboratory for Synthetic Biology of Traditional Chinese Medicine of Hunan Province,School of Pharmaceutical Sciences,Hunan University of Medicine,Huaihua 418000,ChinaKey Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education,Key Laboratory for Green Organic Synthesis and Application of Hunan Province,College of Chemistry,Xiangtan University,Xiangtan 411105,China
化学化工
Palladium catalysisArylaminesCyclohexanonesAmmonium saltsDehydrogenative aromatization
《Green Synthesis and Catalysis》 2026 (1)
P.83-87,5
support from the National Natural Science Foundation of China(Nos.22271244 and 21801076)the Science and Technology Innovation Program of Hunan Province(No.2023RC3196)is gratefully acknowledged.
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