Brønsted acid catalyzed green and efficient construction ofα-amino peroxides from 3-hydroxyisoindolinones and hydroperoxidesOA
A Brønsted acid-catalyzed peroxidation of 3-hydroxyisoindolinones with hydroperoxides has been established for the first time,which constructsα-amino peroxides bearing a tetrasubstituted stereocenter in good to high yields and enantioselectivities.The transformation uses of environmentally benign solvents,and features operational simplicity,and high atom economy.The synthetic utility was demonstrated with the gram-scale reactions and further transformations of the products.Notably,preliminary bioactivity studies reveal that these valuableα-amino peroxides show potential anticancer activity.
Yuming Li;Yaqi Xuan;Yan Gou;Fan Wu;Nan Wang;Nana Fu;Zhi Fan
Department of Chemistry,College of Sciences,Tianjin University of Science and Technology,Tianjin 300457,ChinaCollege of Chemical Engineering and Materials Science,Tianjin University of Science and Technology,Tianjin 300457,ChinaDepartment of Chemistry,College of Sciences,Tianjin University of Science and Technology,Tianjin 300457,ChinaCollege of Marine and Environmental Sciences,Tianjin University of Science and Technology,Tianjin 300457,ChinaCollege of Marine and Environmental Sciences,Tianjin University of Science and Technology,Tianjin 300457,ChinaCollege of Marine and Environmental Sciences,Tianjin University of Science and Technology,Tianjin 300457,ChinaCollege of Chemical Engineering and Materials Science,Tianjin University of Science and Technology,Tianjin 300457,China
化学化工
Brønsted acid catalyzedPeroxidationa-Amino peroxidesGreen synthesis
《Green Synthesis and Catalysis》 2026 (1)
P.105-109,5
supported by the National Natural Science Foundation of China(No.52173044)we thank Dr.Fengchao Wang(Instrumental Analysis and Research Center,Tianjin University of Traditional Chinese Medicine)for providing biological activity testing.
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