Transition metal-free thiophene construction in pure water by multiplied C-H functionalization with enaminones and elemental sulfurOA
A novel method for the synthesis of 2,4-disubstituted thiophenes via the reactions of N,N-disubstituted enaminones and elemental sulfur is developed.By simply heating the substrates in pure water in the presence of NaOH,the thiophene annulation practically takes place via the generation of one C-C and two C-S bonds via cascade dual C-H functionalization and C-N bond thiolation without using any transition metal reagent.
Lihong Tian;Jie-Ping Wan;Yunyun Liu
Jiangxi Province Key Laboratory of Natural and Biomimetic Drugs Research,College of Chemistry and Materials,Jiangxi Normal University,Nanchang 330022,ChinaJiangxi Province Key Laboratory of Natural and Biomimetic Drugs Research,College of Chemistry and Materials,Jiangxi Normal University,Nanchang 330022,ChinaJiangxi Province Key Laboratory of Natural and Biomimetic Drugs Research,College of Chemistry and Materials,Jiangxi Normal University,Nanchang 330022,China
化学化工
EnaminonesElemental sulfurThiophenesTransition metal-freeIn water
《Green Synthesis and Catalysis》 2026 (1)
P.110-113,4
supported by the National Natural Science Foundation of China(No.22261026).
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