Iron-catalyzed non-directed arene C-H difluoromethylationOA
Practical,undirected and selective catalytic functionalization of unactivated arenes remains a challenging problem in organic synthesis.We herein report a bioinspired L-cystine-derived ligand BCPOM/Fe-enabled innate C-H difluoromethylation of unactivated arenes as limiting reagents with stable and inexpensive BrCF_(2)CO_(2)Et as the difluoromethylation source in high efficiency.Notably,this method uses environmentally benign H_(2)O_(2) as the sole oxidant,and enables late-stage functionalization and exceptionally functional-group tolerance,even including oxidation-labile aldehyde,phenolic hydroxy,primary amine,and boronic acid groups,which is difficult to access by current means.
Zhiyuan Yang;Mengying Guo;Lulu Zhou;Hui Zhang;Dongmei Sun;Minnan Chen;Kangkang Sun;Wei-Jin Gu;Wei Han
Jiangsu Collaborative Innovation Center of Biomedical Functional Materials,Jiangsu Key Laboratory of Biofunctional Materials,Key Laboratory of Applied Photochemistry,School of Chemistry and Materials Science,Nanjing Normal University,Nanjing 210023,ChinaJiangsu Collaborative Innovation Center of Biomedical Functional Materials,Jiangsu Key Laboratory of Biofunctional Materials,Key Laboratory of Applied Photochemistry,School of Chemistry and Materials Science,Nanjing Normal University,Nanjing 210023,ChinaJiangsu Collaborative Innovation Center of Biomedical Functional Materials,Jiangsu Key Laboratory of Biofunctional Materials,Key Laboratory of Applied Photochemistry,School of Chemistry and Materials Science,Nanjing Normal University,Nanjing 210023,ChinaJiangsu Collaborative Innovation Center of Biomedical Functional Materials,Jiangsu Key Laboratory of Biofunctional Materials,Key Laboratory of Applied Photochemistry,School of Chemistry and Materials Science,Nanjing Normal University,Nanjing 210023,ChinaJiangsu Collaborative Innovation Center of Biomedical Functional Materials,Jiangsu Key Laboratory of Biofunctional Materials,Key Laboratory of Applied Photochemistry,School of Chemistry and Materials Science,Nanjing Normal University,Nanjing 210023,ChinaJiangsu Collaborative Innovation Center of Biomedical Functional Materials,Jiangsu Key Laboratory of Biofunctional Materials,Key Laboratory of Applied Photochemistry,School of Chemistry and Materials Science,Nanjing Normal University,Nanjing 210023,ChinaJiangsu Collaborative Innovation Center of Biomedical Functional Materials,Jiangsu Key Laboratory of Biofunctional Materials,Key Laboratory of Applied Photochemistry,School of Chemistry and Materials Science,Nanjing Normal University,Nanjing 210023,ChinaJiangsu Collaborative Innovation Center of Biomedical Functional Materials,Jiangsu Key Laboratory of Biofunctional Materials,Key Laboratory of Applied Photochemistry,School of Chemistry and Materials Science,Nanjing Normal University,Nanjing 210023,ChinaJiangsu Collaborative Innovation Center of Biomedical Functional Materials,Jiangsu Key Laboratory of Biofunctional Materials,Key Laboratory of Applied Photochemistry,School of Chemistry and Materials Science,Nanjing Normal University,Nanjing 210023,China
化学化工
Iron catalysisArenesDifluoromethylationH_(2)O_(2)Late-stage functionalization
《Green Synthesis and Catalysis》 2026 (1)
P.114-118,5
sponsored by the Natural Science Foundation of China(Nos.22371126,21776139 and 22072067)the“Qing Lan Project”Young and Middle-aged Academic Leaders of Jiangsu Provincial Colleges and Universities,the Natural Science Foundation of Jiangsu Province(No.BK20161553)the Priority Academic Program Development of Jiangsu Higher Education Institutions.
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