Rare Multiple Brain Metastases Following Debulking Surgery and Androgen Deprivation Therapy in Aggressive Prostate Cancer-Case ReportOA
Background:In clinical practice,approximately 80%of prostate cancer(PC)cases are localized and can achieve favorable outcomes with appropriate treatment.Conversely,some remaining cases exhibit an aggressive phenotype or develop resistance to therapeutic interventions,leading to tumor metastasis and a poorer prognosis.When PC metastasizes to distant sites,the bone remains the predominant location,and brain metastases are regarded as exceedingly rare.Case Description:The current study focused on a rare clinical PC case that presented multiple brain metastases after prostate surgery.The patient was initially diagnosed with PC through prostate biopsy and subsequently underwent prostate debulking surgery while continuing androgen deprivation therapy,which maintained low prostatespecific antigen(PSA)levels for 4 years.However,a sudden PSA surge to 7.858 ng/mL led to the emergence of two brain metastatic tumors,which were confirmed to have originated from the prostate.Conclusions:Patients with advanced PC require comprehensive evaluations to detect rare metastatic sites,such as the brain,to avoid missed diagnoses.For patients with brain metastases,a multimodal approach combining surgical resection,postoperative radiotherapy,and endocrine therapy can effectively alleviate symptoms and enhance survival.
Andong Cheng;Yiding Chen;Hao Li;Feixiang Yang;Junlan Jiang;Sheng Tai;Weiwei Chen;Yu Guan;Shuiping Yin;Jialin Meng
Department of Urology,The First Affiliated Hospital of Anhui Medical University,Institute of Urology,and Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation,Anhui Medical University,Hefei,230001,China School of Life Sciences,Anhui Medical University,Hefei,230032,ChinaDepartment of Urology,The First Affiliated Hospital of Anhui Medical University,Institute of Urology,and Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation,Anhui Medical University,Hefei,230001,ChinaDepartment of Urology,The First Affiliated Hospital of Anhui Medical University,Institute of Urology,and Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation,Anhui Medical University,Hefei,230001,ChinaDepartment of Urology,The First Affiliated Hospital of Anhui Medical University,Institute of Urology,and Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation,Anhui Medical University,Hefei,230001,ChinaDepartment of Pathology,The First Affiliated Hospital of Anhui Medical University,Hefei,230001,ChinaDepartment of Urology,The First Affiliated Hospital of Anhui Medical University,Institute of Urology,and Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation,Anhui Medical University,Hefei,230001,ChinaDepartment of Neurosurgery,The First Affiliated Hospital of Anhui Medical University,Hefei,230001,ChinaDepartment of Urology,The First Affiliated Hospital of Anhui Medical University,Institute of Urology,and Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation,Anhui Medical University,Hefei,230001,ChinaDepartment of Urology,The First Affiliated Hospital of Anhui Medical University,Institute of Urology,and Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation,Anhui Medical University,Hefei,230001,ChinaDepartment of Urology,The First Affiliated Hospital of Anhui Medical University,Institute of Urology,and Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation,Anhui Medical University,Hefei,230001,China School of Life Sciences,Anhui Medical University,Hefei,230032,China
医药卫生
Prostate cancerbrain metastasesmetastatic prostate cancercastration-resistant prostate cancercase report
《Oncology Research》 2026 (2)
P.631-641,11
supported by the National Natural Science Foundation[Grant Number:82102788]Anhui Province Key Project for Clinical Medical Research Translation and Advancement[202204295107020031,202204295107020007]Anhui Provincial University Excellent Scientific Research and Innovation Team Project[2022AH010071].
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