肝细胞癌中脂肪酸代谢的研究进展OA

Hepatocellular carcinoma(HCC)is a globally prevalent malignant tumor,characterized by persistently high incidence and mortality rates.The pathogenesis of HCC is multifactorial,with dysregulated lipid metabolism emerging as a critical factor.In HCC,the anabolic pathways of fatty acid synthesis are markedly upregulated,with key enzymes such as ATP-citrate lyase,acetyl-CoA carboxylase,fatty acid synthase,and stearoyl-Coenzyme A desaturase 1 being overexpressed in HCC tissues,thereby facilitating tumor growth and progression.Moreover,fatty acid oxidation plays a vital role in HCC cells,especially under conditions of glucose deprivation,as it serves as an alternative energy source.Sterol regulatory element-binding proteins and peroxisome proliferators-activated receptors function as key regulatory factors that modulate the synthesis and catabolism of fatty acids.Strategic inhibition of these enzymes could effectively arrest tumor development,paving new avenues for cancer therapeutic interventions.Hence,this review synthesizes the research advancements in fatty acid metabolism-related proteins and genes in the occurrence and development of HCC,with the aim of providing novel perspectives for lipid metabolism-targeted therapeutic strategies against HCC.