循环脂肪因子水平与乳腺癌关系的孟德尔随机化研究OA

Objective To investigate relationship between circulating adipokines and the risk of breast cancer.Methods Two-sample Mendelian randomization study design was employed,using single nucleotide polymorphisms associated with the expression levels of leptin,adiponectin,resistin(RETN),and fatty acid-binding protein 4(FABP4)as instrumental variables.Outcome event data were derived from the Breast Cancer Genome Wide Association Study.Causal effect values were calculated using inverse-variance weighted(IVW),MR Egger,weighted median,simple mode,and weighted mode methods.Heterogeneity was assessed using the Cochran's Q test,and horizontal heterogeneity was examined with the MR Egger intercept test.Sensitivity analysis was performed using the leave-one-out method.Subgroup analysis was conducted based on the estrogen receptor(ER)status in breast cancer.Results IVW analysis revealed that elevated circulating RETN and FABP4 expression levels were associated with increased risk of ER+breast cancer.The leave-one-out method analysis demonstrated stable results.Conclusion The circulating levels of RETN and FABP4 may be causally associated with the occurrence of ER+breast cancer.