肥胖患儿代谢功能障碍相关脂肪性肝病患病因素分析OA

Objective To explore the variation patterns and clinical significance of clinical indicators and homeostasis model assessment for insulin resistance index(HOMA-IR)in metabolic dysfunction-associated steatotic liver disease(MASLD)in obese children.Methods A total of 138 obses pediatric patients admitted to the Third Affiliated Hospital of Soochow University,Changzhou First People's Hospital from May 2023 to September 2025 were selected as the study subjects.Based on the presence or absence of MASLD,the patients were divided into simple obesity group(n=79)and MASLD group(n=59).Clinical indicators of two groups were compared,and multivariate Logistic regression analysis was performed to identify risk factors for MASLD in obese children.Results The age and levels of alanine aminotransferase,aspartate aminotransferase,triglycerides,25-hydroxyvitamin D,and HOMA-IR in MSLD group were significantly higher than those in simple obesity group(P<0.05).Logistic regression analysis revealed that HOMA-IR was an independent risk factor for the development of fatty liver in obese children.Conclusion When the HOMA-IR level of obese children is significantly elevated,the risk of MASLD should be monitored and evaluated.