首页|期刊导航|中西医结合肝病杂志|消膏降浊法治疗肥胖合并代谢相关脂肪性肝病验案1例

消膏降浊法治疗肥胖合并代谢相关脂肪性肝病验案1例OA

A case report on the treatment of obesity combined with metabolic dysfunction-associated fatty liver disease using the fat-reducing and turbidity-resolving method

中文摘要英文摘要

本文报道1 例"消膏降浊"法治疗肥胖合并代谢相关脂肪性肝病(MAFLD)的临床验案,治疗以消膏化浊、疏瀹气机为核心治则,选用小陷胸汤合厚朴三物汤加减,并随证动态化裁.经 3.5 个月系统干预,患者体重下降12.5 kg,BMI降至26.9 kg/m2,腰围减少 12.5 cm,体脂率降低 6.9%;肝脏脂肪沉积(CAP 254 dB/m)及硬度(LSM 7.6 kPa)显著改善,代谢指标(血糖、胰岛素、尿酸等)均趋于正常范围.结果表明,以仝小林院士"膏浊病"理论为指导的"消膏降浊"治法,融合"肥肝同调"的整体观念与"态靶结合"治疗策略,可有效逆转肥胖合并MAFLD的代谢紊乱和肝脏病理变化,为代谢性疾病的中医药治疗提供了可借鉴的临床路径与实践依据.

This paper reports a clinical case of obesity combined with metabolic dysfunction-associated fatty liver disease(MAFLD)treated with the"Clearing Fat and Reducing Turbidity"method.The treatment was based on the core principles of eliminating fat accumulations,resolving turbidity,and regulating qi movement,using a modified Xiaoxianxiong Decoction combined with Houpo Sanwu Decoction,with dynamic adjustments made according to syndrome differentiation.After 3.5 months of systematic intervention,the patient's body weight decreased by 12.5 kg,BMI dropped to 26.9 kg/m2,waist circumference reduced by 12.5 cm,and body fat percentage decreased by 6.9%.Hepatic fat deposition(CAP 254 dB/m)and liver stiffness(LSM 7.6 kPa)were significantly improved,and metabolic indicators(blood glucose,insulin,uric acid,etc.)all returned to the normal range.The results indicate that the"Clearing Fat and Reducing Turbidity"method,guided by Academician Tong Xiaolin's"Fat-Turbidity Disease"theory and integrating the holistic concept of"simultaneously regulating obesity and liver"with the"state-target combination"treatment strategy,can effectively reverse metabolic disorders and hepatic pathological changes in obesity combined with MAFLD.This provides a referential clinical pathway and practical evidence for the treatment of metabolic diseases with traditional Chinese medicine.

吴哲骁;朱绘;李紫明;任朦;肖明中;李晓东

湖北中医药大学中医学院(湖北 武汉,430065)湖北省中医院肝病研究所 中医肝肾研究及应用湖北省重点实验室||湖北时珍实验室||湖北中医药大学附属医院湖北中医药大学中医学院(湖北 武汉,430065)湖北省中医院肝病研究所 中医肝肾研究及应用湖北省重点实验室||湖北时珍实验室||湖北中医药大学附属医院湖北省中医院肝病研究所 中医肝肾研究及应用湖北省重点实验室||湖北时珍实验室||湖北中医药大学附属医院湖北省中医院肝病研究所 中医肝肾研究及应用湖北省重点实验室||湖北时珍实验室||湖北中医药大学附属医院

医药卫生

肥胖代谢相关脂肪性肝病膏浊病态靶理论

obesityMetabolic dysfunction-associated fatty liver disease(MAFLD)fat-turbidity diseasestate-target theory

《中西医结合肝病杂志》 2026 (3)

370-373,4

国家自然科学基金面上项目(No.82274352),湖北省自然科学基金创新群体项目(No.2020CFA023),湖北省自然科学基金(No.2023AFD178)

10.3969/j.issn.1005-0264.2026.003.020

评论