肝癌伴微血管侵犯患者术后的无瘤生存风险因素分析OA
Analysis of risk factors for tumor-free survival in patients with liver cancer accompanied by microvascular invasion after surgery
目的:探讨单发肝癌伴微血管侵犯患者精准肝切除术后系统免疫炎症指数(SII)、全身炎症反应指数(SIRI)、白蛋白-胆红素(ALBI)分级变化与无瘤生存的关系.方法:回顾性纳入2017 年1 月至2020 年12 在沧州市人民医院行精准肝切除术的单发肝癌伴微血管侵犯患者100 例作为本次研究对象,根据随访情况分为无瘤生存<5 年和无瘤生存≥5 年.ROC曲线下面积预测SII、SIRI及ALBI分级预测无瘤生存期的诊断价值,采用COX 回归分析单发肝癌伴微血管侵犯患者无瘤生存期的影响因素.结果:无瘤生存<5 年的患者PLT、NEU、AMC、GGT、SII、SIRI及ALBI分级2～3 级占比明显高于无瘤生存≥5 年的患者(P<0.05);SII、SIRI、ALBI分级及联合诊断预测无瘤生存期的曲线下面积为0.771(95%CI 0.658～0.884,P<0.001)、0.817(95%CI 0.713～0.922,P<0.001)、0.833(95%CI 0.738～0.929,P<0.001)、0.887(95%CI 0.810～0.964,P<0.001);PLT、NEU、AMC、GGT、SII、SIRI、ALBI分级是单发肝癌伴微血管侵犯患者精准肝切除术后无瘤生存期的独立影响因素(P<0.05).结论:单发肝癌伴微血管侵犯患者精准肝切除术后SII、SIRI、ALBI分级与无瘤生存相关.
Objective:To explore the relationship between the changes in systemic immune inflammatory index(SII),systemic inflammatory response index(SIRI),and albumin-bilirubin(ALBI)grade after precise liver resection in patients with solitary liver cancer accompanied by microvascular invasion and tumor-free survival.Methods:A retrospective analysis of 100 patients with single hepatocellular carcinoma accompanied by microvascular invasion who underwent precise liver resection in our hospital from January 2017 to December 2020 was conducted as the research subjects.According to the follow-up situation,they were divided into tumor-free survival<5 years and tumor-free survival≥5 years.The area under the ROC curve predicted the diagnostic value of SII,SIRI,and ALBI grading for tumor-free survival.Cox regression analysis was used to determine the influencing factors of tumor-free survival in patients with single hepatocellular carcinoma accompanied by microvascular invasion.Results:The proportion of PLT,NEU,AMC,GGT,SII,SIRI,and ALBI grades 2-3 in patients with tumor free survival<5 years was significantly higher than that in patients with tumor free survival≥5 years(P<0.05);The area under the curve for predicting tumor free survival using SII,SIRI,ALBI grading,and combined diagnosis is 0.771(95%CI=0.658-0.884,P<0.001)、0.817(95%CI=0.713-0.922,P<0.001)、0.833(95%CI=0.738-0.929,P<0.001)、0.887(95%CI=0.810-0.964,P<0.001);PLT,NEU,AMC,GGT,SII,SIRI,and ALBI grading are independent factors affecting the tumor free survival of patients with single liver cancer and microvascular invasion after precision liver resection(P<0.05).Conclusion:In patients with solitary liver cancer accompanied by microvascular invasion,the SII,SIRI,and ALBI grading after precise liver resection are associated with tumor-free survival.
胡涛;苑建磊;王钊;张昀昊
沧州市人民医院肝胆胰微创外科(河北 沧州,061000)沧州市人民医院肝胆胰微创外科(河北 沧州,061000)沧州市人民医院肝胆胰微创外科(河北 沧州,061000)沧州市人民医院肝胆胰微创外科(河北 沧州,061000)
医药卫生
单发肝癌SIISIRIALBI分级无瘤生存
unifocal liver cancerSIIsystemic immune-inflammation response indexALBI gradingtumor-free survival
《中西医结合肝病杂志》 2026 (3)
271-274,4
河北省医学科学研究课题计划(No.20220319)
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