"气化五行"视角下五脏-线粒体功能映射关系的构建OA

Based on"qi transforming into the five phases"theory,this study constructs a conceptual correspon-dence between the five zang(脏)organs and mitochondrial function in modern medicine,with mitochondrial quality control(MQC)serving as the core regulatory mechanism to interpret the fucntions of zang organs.Through theoretical synthesis and cross-system structural mapping,a five zang organs-mitochondrial functional mapping framework is pro-posed.In this framework,the spleen is aligned with mitochondrial metabolic networks,while the kidney with mito-chondrial genetics and energy transfer,the liver with mitochondrial metabolic regulation and detoxification,the heart with cardiomyocyte mitochondrial density and metabolic activity,and the lung with mitochondrial redox regulation and signaling control.Furthermore,the intrinsic associations between the physiological characteristics of the five zang organs and the MQC system are identified,which is manifested as structural correspondence and regulatory coordina-tion between zang organ functional activities and mitochondrial homeostasis.