结合中医理论探究干眼症发病机制与临床治疗研究进展OA
Research progress on pathogenesis and clinical treatment of dry eye disease through the lens of traditional Chinese medicine theory
干眼症作为多因素介导的慢性眼表疾病,现代医学依据维持泪膜稳定的要素将其分为蒸发过强型、水液缺乏型等五类;而中医学基于脏腑辨证基础理论提出燥热伤肺、肺阴亏虚等辨证分型.本研究主要梳理基于中西医理论的干眼症发病机制:西医层面主要表现为炎症、细胞凋亡、神经调节及激素失调等;中医层面则涉及脏腑功能失调、外感六邪等病机.干眼症治疗方法多样,包括物理治疗、药物治疗、手术治疗和中医治疗,且治疗策略发展呈现多元化趋势,本研究强调基于中医整体观发展的"病证结合"诊疗模式相较于单纯西医治疗的优势.
Dry eye disease,a multifactorial-mediated chronic ocular surface disease,is classified into five categories includ-ing the hyperevaporative type and aqueous-deficient type in modern medicine according to the key factors maintaining tear film stability.In contrast,Traditional Chinese Medicine(TCM)proposes pattern differentiation categories such as"dry-heat injuring the lung"and"lung yin deficiency"rooted in visceral pattern differentiation theory.This paper systematically elucidates the patho-genesis of DED through dual theoretical frameworks:The manifestations in Western medicine primarily include inflammation,apoptosis,neuroregulation disorders,hormonal imbalances and other related factors,while TCM attributes the disease to zang-fu functional disorders and invasion of six exogenous pathogenic factors.Diverse therapeutic approaches include physical therapy,pharmacotherapy,surgery,and TCM interventions,with treatment strategies evolving multidimensional integration.The study highlights the superiority of the"disease-pattern combination"diagnostic model development under TCM's holistic philosophy compared to Western medicine alone.
刘琳;蒋宇旋;李曦;吴志城;杨明晓;宋敏;叶章楷;刘晖;叶强
成都中医药大学,四川成都 611137成都中医药大学,四川成都 611137成都中医药大学,四川成都 611137成都中医药大学,四川成都 611137成都中医药大学,四川成都 611137成都中医药大学,四川成都 611137新疆师范大学,新疆乌鲁木齐,830017新疆师范大学,新疆乌鲁木齐,830017成都中医药大学,四川成都 611137
医药卫生
干眼症发病机制辨证分型治疗方法中西医结合
Dry eye diseasepathogenesissyndrome differentiation and classificationtreatment methodsintegrated tradi-tional Chinese and western therapy
《中药与临床》 2026 (2)
50-56,7
国家自然基金区域重点项目(U24A20790)四川省中医药管理局科学技术研究专项(2024ZD02)
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