7种口服中成药治疗脑卒中恢复期有效性和安全性的网状Meta分析OA

Objective:To evaluate the efficacy and safety of 7 kinds of Chinese patent medicines combined with conven-tional western medicine in the treatment of patients with stroke recovery,and to provide evidence-based basis for clinical decision-making optimization.Methods:The evaluation was performed based on network meta-analysis,and the statistical analysis of data results was conducted using R language packages.Results:A total of 19 RCTs were included,involving 1 832 patients.The re-sults of effectiveness analysis showed that(1)in terms of total effective rate,Tongxinluo capsule combined treatment had the best curative effect(SUCRA=0.3873);(2)In terms of improvement of NIHSS and ALD:Nao'an capsule combined treatment was the most significant(SUCRA=0.693 5;SUCRA=0.389 1);(3)In terms of TCM syndrome score and mRS score:Duzhi pill combined treatment had statistical advantages(MD=4.87,95％CI=-1.46-11.22;MD=1.12,95％CI=0.21-2.01);(4)In terms of Safety analy-sis:Duzhi Pills combined with CT had the lowest risk of adverse reactions(SUCRA=0.745 2).Conclusion:Combined therapy with seven kinds of Chinese patent medicines can improve neurological function and daily living ability in patients during the re-covery stage of stroke,among which Tongxinluo Capsule,Nao'an Capsule and Duzhi Pill exhibited prominent efficacy with spe-cific outcome indicators.