针灸干预阿尔茨海默病的神经炎症机制研究进展OA
Research progress on neuroinflammatory mechanisms of acupuncture-moxibustion intervening Alzheimer disease
收集、梳理针灸干预阿尔茨海默病(AD)的相关文献,总结针灸通过抑制小胶质细胞和星形胶质细胞的异常活化状态、纠正小胶质细胞的极化失衡状态、上调免疫受体髓样细胞触发受体2(TREM2)和补体相关蛋白(C1q)的表达、下调炎症小体核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)的表达、调节促炎/抗炎细胞因子的释放、降低炎性介质环氧合酶-2(COX-2)和转化生长因子-β1(TGF-β1)的释放、抑制Janus激酶2(JAK2)/信号转导与转录激活因子3(STAT3)及核因子κB(NF-κB)、高迁移率族蛋白B1(HMGB1)/晚期糖基化终末产物受体(RAGE)、p38丝裂原活化蛋白激酶(p38 MAPK)信号通路的异常激活,上调白细胞介素(IL)-33/生长刺激表达基因2蛋白(ST2)信号通路的分子水平,发挥治疗AD的作用.
Relevant studies on acupuncture-moxibustion intervening Alzheimer disease(AD)were collected,sorted out,and summarized,and acupuncture-moxibustion plays its role in treating AD via the following aspects:inhibiting abnormal activation of microglia and astrocytes;correcting imbalanced polarization of microglia;upregulating the expression of triggering receptor expressed on myeloid cells 2(TREM2)and component 1q(C1q);downregulating nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3);regulating the release of proinflammatory/anti-inflammatory factors;reducing the release of cyclooxygenase-2(COX-2)and transforming growth factor-β1(TGF-β1);suppressing the abnormal activation of Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3),nuclear factor-κB(NF-κB),high mobility group box 1(HMGB1)/receptor for advanced glycation end products(RAGE),and p38 mitogen-activated protein kinase(p38 MAPK)pathways;and upregulating molecule levels of the interleukin(IL)-33/growth stimulating gene 2 protein(ST2)pathway.
李丽;严兴科;马翠;魏玉婷;窦婷婷;谢雯婷;洪珏
医药卫生
针灸疗法针刺疗法灸法阿尔茨海默病信号传导神经炎症
Acupuncture-moxibustion TherapyAcupuncture TherapyMoxibustion TherapyAlzheimer DiseaseSignal TransductionNeuroinflammation
《针灸推拿医学（英文版）》 2026 (2)
190-199,10
This study was supported by 2023 Key Talent Project of Gansu Province[2023年甘肃省省级重点人才项目,No.Gan Zu Tong Zi(2023)20 Hao]2024 University Teacher Innovation Fund Project(2024年高校教师创新基金项目,No.2024A-082)Research Startup Fund Project for Invited Talents of Gansu University of Chinese Medicine(甘肃中医药大学引进人才科研启动基金项目,No.2024YJRC-06).
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