脂联素对动物内质网应激的调控作用研究进展OA

Endoplasmic reticulum(ER)stress is a key response of animal cells to protein folding imbalance,closely related to various diseases such as fatty liver disease,poultry follicular atresia,bovine mastitis,bovine ketosis,enteritis,etc.Adiponectin is a multifunctional hormone secreted by adipose tissue that has biological effects such as regulating glucose and lipid metabolism,insulin sensitization,anti-inflammatory,antioxidant stress,regulating cell apoptosis and autophagy.Researches have indicated that adiponectin can regulate ER stress,protein and lipid synthesis,as well as cell apoptosis and survival through multiple signaling pathways such as AMPK/PPAR α/mTOR,improving inflammation and glucose and lipid metabolism in the body,and playing an important role in livestock and poultry related diseases.This article reviews ER stress and its important signaling pathways,the impact of ER stress on livestock and poultry related diseases,and the synergistic regulation of ER stress by adiponectin through multiple pathways to improve the process of related diseases.The aim is to provide new ideas for the development of clinical drugs targeting ER stress and the regulation of livestock and poultry stress.