中药传统制剂丸剂研究进展OA

As a classic solid dosage form in traditional Chinese medicine,traditional Chinese medicine pills are widely used in the treatment of chronic diseases due to their advantages of convenient administration and long-lasting efficacy.The significant progress had been made in production technology,process optimization,and quality control with the deep integration of modern technology and traditional pharmaceutical concepts.In terms of production technology and preparation processes,modern extraction and concentration,intelligent grinding and mixing,the application of new excipients,and the development of micro-pellet and drop-pellet forming technologies had enhanced the uniformity,stability,and production efficiency of pills.New technologies such as vacuum pulsating drying,microwave drying,and controlled-release coating had further optimized the physical properties and release performanceof pills. In quality control,research had shifted from single-component determination to comprehensive evaluation ofmultiple indicators. Holistic evaluation methods such as fingerprint chromatography,quality markers,biologicalfingerprint chromatography,and reference preparations of traditional Chinese medicine provide scientific support forquality consistency. The modernization of Chinese herbal pills still faces some challenges. The preparation of pillsinvolves the compatibility of multiple herbs and complex processes,and the quality control system still needs to befurther improved to enhance the uniformity of pill quality. It is necessary to strengthen multi-disciplinary collaborativeinnovation,conduct cross-disciplinary systematic research by integrating powder engineering and intelligent manufacturingto optimize processes,and adopt technologies such as controlled-release,multi-layer formulations,and intelligentresponses to promote the development of Chinese herbal pills towards precision and intelligence.