复心合剂对老年主动瓣狭窄诱发心力衰竭保守治疗患者的临床疗效OA
Clinical effects of Fuxin Mixture on elderly patients with heart failure induced by aortic valve stenosis following conservative treatment
目的 探讨复心合剂对老年主动瓣狭窄诱发心力衰竭保守治疗患者的临床疗效.方法 86 例患者随机分为对照组和观察组,每组 43 例,对照组给予常规治疗,观察组在对照组基础上加用复心合剂,疗程 2 个月.检测临床疗效、左心室功能指标(舒张末期内径、质量指数、重构指数、射血分数)、三维斑点追踪超声心动图指标(左室整体纵向应变、左室整体环向应变、左室整体径向应变)、左室心肌做功指标(整体做功指数、整体有用功、整体无用功)、实验室指标(缺血修饰蛋白、N末端B型利钠肽前体、巨噬细胞炎症蛋白-1α)、中医证候评分、心率变异性指标(R波时间间隔方均根、RR 间期标准差、所有 5 min 段中 NN 间隔标准偏差的平均值)、安全性指标变化.结果 观察组总有效率高于对照组(P＜0.05).治疗后,2 组舒张末期内径、质量指数、重构指数、整体无用功、实验室指标、中医证候评分、心率变异性指标降低(P＜0.05),整体做功指数、整体有用功、射血分数、三维斑点追踪超声心动图指标升高(P＜0.05),以观察组更明显(P＜0.05).2 组未出现不良反应.结论 复心合剂可安全有效地提高老年主动瓣狭窄诱发心力衰竭保守治疗患者心功能,改善左室重构.
AIM To explore the clinical effects of Fuxin Mixture on elderly patients with heart failure induced by aortic valve stenosis following conservative treatment.METHODS Eighty-six patients were randomly assigned into control group(43 cases)for 2-month intervention of conventional treatment,and observation group(43 cases)for 2-month intervention of both Fuxin Mixture and conventional treatment.The changes in clinical effects,left ventricular function indices(end-diastolic diameter,mass index,remodeling index,ejection fraction),three-dimensional speckle-tracking echocardiography indices(left ventricular overall longitudinal strain,left ventricular overall circumferential strain,left ventricular overall radial strain),left ventricular myocardial work indices(overall work index,overall useful work,overall useless work),laboratory indices(ischemia-modified protein,N-terminal pro-B-type natriuretic peptide,macrophage inflammatory protein-1α),TCM syndrome scores,heart rate variability indices(root mean square of successive RR intervals,standard deviation of RR intervals,average standard deviation of NN intervals over 5 min segments)and safety indices were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P＜0.05).After the treatment,the two groups displayed decreased end-diastolic diameter,mass index,remodeling index,mass index,remodeling index,mass index,remodeling index,mass index,remodeling index,mass index,remodeling index,overall useless work,laboratory indices,TCM syndrome scores,heart rate variability indices(P＜0.05),and increased overall work index,overall useful work,ejection fraction,three-dimensional speckle-tracking echocardiography indices(P＜0.05),especially for the observation group(P＜0.05).No adverse reactions were observable in the two groups.CONCLUSION For the elderly patients with heart failure induced by aortic valve stenosis following conservative treatment,Fuxin Mixture can safely and effectively enhance cardiac functions and improve left ventricular remodeling.
张娟;张倩;丛丛;张冰睿;孔立
山东中医药大学附属医院心血管二科,山东 济南 250014||山东中医药大学第一临床医学院,山东 济南 250014||山东齐都药业有限公司,山东 淄博 255420山东中医药大学附属医院科技处,山东 济南 250014山东中医药大学附属医院心血管二科,山东 济南 250014山东中医药大学附属医院心血管二科,山东 济南 250014山东中医药大学附属医院重症医学科,山东 济南 250014
医药卫生
复心合剂常规治疗主动瓣狭窄心力衰竭保守治疗左心室功能心肌做功心率变异性
Fuxin Mixtureconventional treatmentaortic valve stenosisheart failureconservative treatmentleft ventricular functionsmyocardial workheart rate variability
《中成药》 2026 (3)
816-821,6
山东省自然科学基金面上项目(ZR2024MH244)山东省自然科学基金联合基金重点支持项目(ZR2021LZY038)山东省中医药科技发展计划项目(2021M181)山东省老年医学学会2021年科技攻关项目(LKJGG2021W106)齐鲁流派中医学术流派传承项目(鲁卫函[2022]93号)山东省中医药特色疗法挖掘整理项目(3700020699)
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