舒泰参与的静吸联合麻醉方案对兔的全麻效果及安全性OA
The Effects and Safety of General Anesthesia in Rabbits Using Combined Intravenous and Inhalational Anesthesia Schemes Involving Telazol
为了确定兔静吸联合麻醉方案中舒泰的安全剂量,对方案的麻醉效果,和药物对心血管功能、呼吸功能和肾脏的影响进行评价.本实验中,按照舒泰给药剂量将参与静吸联合麻醉的家兔分为高、中、低三个剂量组,将溴莫尼定、舒泰和利多卡因静脉注射与 2%异氟烷吸入 5 min联合诱导,之后静脉持续输注与1%异氟烷吸入联合维持2 h;检查2h内麻醉对呼吸和心血管功能的影响,给药24 h后测量肾功能,并将肾脏取材做病理学观察.结果显示:静吸联合麻醉的各组兔,均能持续麻醉2 h.低剂量组在第120 min时出现血压下降.静吸联合麻醉的低剂量组肾功能和肾脏病理无明显异常,而高、中剂量组的兔,虽然肾功能未见明显异常,但肾脏病理有异常.结果表明,舒泰参与的静吸联合麻醉方案对兔的麻醉效果稳定,对心血管动力学和呼吸功能影响较小,但只有静吸联合麻醉低剂量组的肾脏病理无异常;而使用更高剂量舒泰的方案对兔有肾毒性.提示已有含舒泰的兔全身麻醉方案有毒性风险,研究提供了新的静吸联合麻醉方案,把舒泰剂量控制在安全剂量范围内.
To determine the safe dose of telazol in the combined intravenous-inhalational anesthesia protocol for rabbits,an evaluation was conducted on the anesthetic effect of the protocol,as well as the impacts of the drug on cardiovascular function,respiratory function,and renal function.In this experiment,rabbits undergoing combined intravenous-inhalational anesthesia were divided into high,medium and low doseage groups based on the the administration dose of telazol.Anesthesia induction was achieved by the combination of intravenous injection of brimonidine,Telazol,and lidocaine,followed by inhalation of 2%isoflurane for 5 minutes.Subsequently,anesthesia maintenance was performed for 2 hours through the combination of continuous intravenous infusion and inhalation of 1%isoflurane.The kidney function and renal histopathology were measured at 24 hours post-administration.The results showed that all groups of rabbits receiving combined intravenous-inhalation anesthesia could maintain anesthesia continuously for 2 hours.During anesthesia,blood pressure and respiratory function remained stable in each group of rabbits.The low-dose group exhibited a decrease in blood pressure at the 120th minute.There were no significant abnormalities in renal function or renal pathology in the low-dose group receiving combined intravenous-inhalational anesthesia.However,for rabbits in the high-dose and medium-dose groups,although no obvious abnormalities were observed in renal function,abnormal changes were found in renal pathology.The results indicated that the combined intravenous-inhalational anesthesia protocol involving telazol exerted a stable anesthetic effect on rabbits and had minimal impacts on cardiovascular dynamics and respiratory function.However,only the low-dose group of the combined intravenous-inhalational anesthesia showed no abnormalities in renal pathology;in contrast,the protocols using higher doses of telazol exhibited nephrotoxicity in rabbits.It is indicated that the existing general anesthesia protocols for rabbits containing telazol carry toxicity risks.This study provides a new combined intravenous-inhalational anesthesia protocol,which controls the dose of telazol within the safe dose range.
张川;刘伟伟;陈斌
天津市医药科学研究所,天津 300020天津市医药科学研究所,天津 300020天津市医药科学研究所,天津 300020
农业科技
静吸联合麻醉舒泰溴莫尼定肾毒性利多卡因兔
combined intravenous-inhalational anesthesiatelazolbrimonidinenephrotoxicitylidocainerabbit
《中国兽药杂志》 2026 (3)
6-13,8
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