基于"久视伤血"理论探讨Piezo通道调控近视的作用机制OA

Based on the Traditional Chinese Medicine(TCM)theory that"prolonged vision impairs the blood"this study systematically investigates the regulatory mechanism of Piezo channels in the development and progression of myopia.The research elucidates the complete biological process through which ocular mechanical stress induced by"prolonged vision"activates Piezo1 channels,promoting excessive reactive oxygen species generation and triggering an oxidative stress cascade,while simultaneously inhibiting intrinsically photosensitive retinal ganglion cell growth and causing dysfunction in retinal ganglion cells,ultimately leading to myopia.From the perspective of TCM theory,the study explores how this process corresponds to the dysfunction described as"the eyes can see when nourished by blood",clarifying the pathogenic progression from deficiency and stasis in the blood-collaterals to collateral damage.The Piezo channel-mediated oxidative stress and cellular injury precisely reflect the pathological transformation of"blood impairment leading to stasis and toxicity".This article not only provides novel insights into the"prolonged vision impairs blood"theory at the biomechanical and molecular levels,establishing a critical bridge between traditional theory and modern mechanisms,but also offers a theoretical foundation and new directions for developing myopia interventions targeting Piezo channels.