基于多组学技术和网络药理学探讨雷公藤制剂生殖毒性减毒增效的研究进展OA

Tripterygium wilfordii preparation has a significant effect in the treatment of autoimmune diseases such as rheuma-toid arthritis and systemic lupus erythematosus,but its repro-ductive toxicity greatly limits its clinical application.Multi-omics technologies(genomics,transcriptomics,proteomics,metabolomics)can systematically analyze the mechanism of re-productive toxicity at the molecular level,and network pharma-cology can construct a regulatory network of'toxic components-core targets-key pathways'.The combination of the two provides a new way to clarify the mechanism of reproductive toxicity of Tripterygium wilfordii and to study the strategy of reducing toxic-ity and increasing efficiency.This paper systematically reviews the material basis and mechanism of reproductive toxicity of Tripterygium wilfordii,and focuses on the application progress of multi-omics technology and network pharmacology in the mechanism analysis of reproductive toxicity of Tripterygium wil-fordii and the strategy of reducing toxicity and increasing effi-ciency,aiming to provide reference for the clinical safe use of Tripterygium wilfordii preparations and the development of new low-toxic preparations.