不同应激下高尔基体自噬的机制及关联研究OA

Golgiphagy,a newly identified selective autophagy pathway,mediates the direct degradation of Golgi components to maintain its structural and functional homeostasis.It serves as a pivotal mechanism in the cellular response to environmental stress and has emerged as a frontier hotspot in cell biology and disease research.Since its initial discovery and naming in 2020,significant breakthroughs have been achieved in the de-velopment of research tools,elucidation of core molecular mechanisms,and exploration of disease associations.This ar-ticle systematically reviews the induction mechanisms of Gol-giphagy under both nutritional and non-nutritional stress condi-tions,elaborates on the compartmentalized,multi-receptor co-operative regulatory network centered around various receptors,and discusses its interplay with other organelles as well as its roles in various diseases.Finally,the challenges and future di-rections in this field are outlined,aiming to facilitate the transla-tion of fundamental research on Golgiphagy toward clinical ap-plications in Golgi medicine.