联会复合体蛋白2与p16、Ki-67蛋白在子宫颈癌组织中的表达及临床意义OA
Expression and clinical significance of synaptonemal complex protein 2,p16,and Ki-67 in cervical cancer tissues
目的 探讨子宫颈癌组织中联会复合体蛋白2(synaptonemal complex protein 2,SYCP2)与p16、Ki-67蛋白的表达,分析其与临床病理特征及预后的关系.方法 选取2018年11月至2021年12月郑州大学第三附属医院病理学明确诊断的124例子宫颈癌患者的病理组织进行SYCP2、p16、Ki-67免疫组织化学法分析.采用生存分析、Cox回归分析法探究三者表达与预后的关系.结果 子宫颈癌患者SYCP2、p16、Ki-67阳性表达率分别为61.3％、76.6％、82.3％,与分化程度、国际妇产科联盟(FIGO)分期、浸润深度、肿瘤最大长径、有无淋巴结转移均有关(P＜0.05).SYCP2与p 16、Ki-67三者表达均呈正相关(P＜0.05);SYCP2、p 16阳性表达患者的3年生存率低于阴性表达者(P＜0.05);FIGO分期、分化程度、浸润深度、淋巴结转移是影响子宫颈癌预后的独立危险因素.结论 SYCP2与p16、Ki-67在子宫颈癌组织中高表达且呈正相关,SYCP2与p16与子宫颈癌患者不良预后相关.
Objective To investigate the expression of synaptonemal complex protein 2,p16,and Ki-67 in cervical cancer tissues,and analyze their relationships with clinicopathological features and prognosis.Methods A total of 124 cases of pathologically confirmed cervical cancer tissues and 60 cases of paracancerous tissues from the Third Affiliated Hospital of Zhengzhou University between November,2018 and December,2021 were selected for immunohistochemical analysis of SYCP2,p 16 and Ki-67,with follow-up conducted thereafter.Results The positive expression rates of SYCP2,p16,and Ki-67 in cervical cancer were 61.29％,76.61％,and 82.26％,respectively,which were correlated with differentiation degree,FIGO stage,invasion depth,maximum tumor diameter,and lymph node metastasis(P＜0.05).Positive correlations were found among SYCP2,p16,and Ki-67(P＜0.05).The 3-year survival rate of patients with positive SYCP2 or p16 was lower than that of negative patients(P＜0.05).FIGO stage,differentiation degree,invasion depth,and lymph node metastasis were independent prognostic risk factors.Conclusion SYCP2,p16,and Ki-67 are highly expressed in cervical cancer tissues and show a positive correlation with each other;SYCP2 and p16 are associated with poor prognosis in patients with cervical cancer.
胡会纳;侯忠臣;朱远航;闫金香;林南山;肖宁;李倩;杨立;任琛琛
郑州大学第三附属医院,妇产科,河南郑州 450052郑州大学第三附属医院,妇产科,河南郑州 450052郑州大学第三附属医院,遗传与产前诊断科,河南郑州 450052郑州大学第三附属医院,病理科,河南郑州 450052郑州大学第二临床医学院,河南郑州 450001郑州大学第三附属医院,妇产科,河南郑州 450052郑州大学第三附属医院,妇产科,河南郑州 450052郑州大学第三附属医院,妇产科,河南郑州 450052郑州大学第三附属医院,妇产科,河南郑州 450052
医药卫生
子宫颈癌联会复合体蛋白2p16Ki-67
cervical cancerSYCP2p16Ki-67
《中国实用妇科与产科杂志》 2026 (3)
361-365,5
Henan Provincial Science and Technology Tackle Program(232102310092)National Key Research and Development Program of China(2022YFC2704103)Henan Science and Technology Innovation Zhongyuan Program(2023HYTP048) 河南省科技攻关项目(232102310092)国家重点研发计划(2022YFC2704103)河南省科创中原项目(2023HYTP048)
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