多囊卵巢综合征合并胰岛素抵抗的中西医整合策略:基于病机互补的协同增效机制探讨OA

Polycystic ovary syndrome(PCOS)with insulin resistance(IR)represents a common complex endocrine-metabolic disorder in reproductive-aged women,posing substantial threats to their reproductive and long-term health.The networked characteristics of pathological mechanisms pose severe challenges in the diagnosis and treatment modes with a single medical system.Western medicine identifies it as a pathological axis with the core of"IR-hyperinsulinemia-hyperandrogenemia"and offers effective symptomatic treatments,it is often faced with limitations such as insufficient overall regulation and drug side effects.Traditional Chinese medicine is characterized by a holistic concept centered on the dysfunction of"kidney-spleen-liver"and syndrome differentiation and treatment,yet its microscopic action mechanisms remain to be fully elucidated.An integrative diagnosis and treatment mode of traditional Chinese medicine and western medicine provides a vital approach to overcoming these challenges.This review systematically sorted out the understanding of polycystic ovary syndrome with insulin resistance(PCOS-IR)pathogenesis from both Chinese and western medicine perspectives.An explainable mapping relation potentially existing between the molecular pathological networks defined by western medicine and the macroscopic dialectical system of traditional Chinese medicine was hypothesized.The synergistic potentiation mechanisms of integrative strategies of traditional Chinese medicine and western medicine were analyzed,with a focus on clarifying the recent progress of integrative diagnosis and treatment strategies.The paper aims to provide a more comprehensive and profound reference for research and clinical practice in this field,advance the further development of the prevention and treatment of PCOS-IR with integrated traditional Chinese medicine and western medicine,and explore the establishment of a more precise,individualized diagnosis and treatment system to make optimal clinical decisions.