基于中西医临床病证特点的慢性痛风性关节炎动物模型分析OA

Objective:Based on the clinical characteristics of chronic gouty arthritis(CGA)in both traditional Chinese and western medicine,this study aims to systematically evaluate the clinical concordance of existing CGA animal models,providing recommendations for establishing animal models that align with the pathological characteristics of CGA and the manifestations of traditional Chinese medicine syndromes.Methods:By comprehensively retrieving Chinese and international databases such as China National Knowledge Infrastructure,Wanfang,VIP Chinese Science and Technology Periodical Database(VIP),and PubMed,all relevant literature on CGA animal models was collected.Based on the guidelines,the diagnostic criteria of both traditional Chinese and western medicine were summarized and organized.The evaluation indicators for the CGA model were constructed with reference to existing evaluation modes,and the CGA animal models were analyzed to systematically evaluate the clinical concordance of existing models.Results:The current methods used to construct CGA animal models mainly include monosodium urate crystal induction,high-protein diet induction(poultry lack urate oxidase),and high-fat diet combined with urate oxidase inhibitors and joint injection.Based on 11 pieces of included literature,the traditional Chinese and western medicine scoring data of each model were extracted,and the average scoring values of all models were ultimately calculated.The results show that the average clinical concordances of existing CGA animal models in both traditional Chinese and western medicine are 43.33％and 64.44％,respectively.Among them,the model with the highest clinical concordance rate is the one with a high-fat diet combined with potassium oxonate to induce hyperuricemia plus joint injection,achieving 83.33％clinical concordance in western medicine and 60％in traditional Chinese medicine.This model aligns well with the pathogenic characteristics and pathological changes of clinical CGA.Conclusion:Although current CGA animal models can simulate some pathological characteristics of CGA,they struggle to comprehensively reflect the complex pathological processes of CGA and the characteristics of traditional Chinese medicine syndromes.Therefore,in the future,it is necessary to establish the CGA animal models that incorporate the clinical disease and syndrome characteristics of traditional Chinese and western medicine and formulate the uniform model evaluation criteria,providing more precise tools for CGA mechanism research and the development of traditional Chinese medicine.