基于AMPK信号通路探讨中医药治疗结直肠癌的研究进展OA

Colorectal cancer is a common malignant tumor of the digestive system.In recent years,its incidence rate and mortality are increasing year by year.Due to the complex pathogenesis and poor prognosis of patients,colorectal cancer poses a serious threat to human physical and mental health.Currently,although Western medicine treatment methods can to some extent inhibit tumor growth and alleviate patient symptoms,postoperative recurrence,metastasis,multiple adverse reactions,and susceptibility to drug resistance are prominent issues,resulting in unsatisfactory overall treatment outcomes.Therefore,exploring more efficient and safe treatment methods has become an urgent task.The adenosine monophosphate-activated protein kinase(AMPK)signaling pathway plays a regulatory role in the growth,differentiation,apoptosis,and autophagy of colorectal cancer cells,and is widely involved in the occurrence and development of colorectal cancer.It is considered an important target for colorectal cancer treatment.Traditional Chinese medicine has unique advantages in the treatment of colorectal cancer,as it can exert its effects through multiple mechanisms and pathways.It can prevent postoperative recurrence and metastasis,reduce adverse reactions to radiotherapy and chemotherapy,and improve patients'quality of life.It has become a key means of treating colorectal cancer.Research has shown that active ingredients in traditional Chinese medicine such as flavonoids,polyphenols,terpenes,and esters,as well as traditional Chinese medicine compounds such as Qingjie Fuzheng Granules and some traditional Chinese medicine extracts,have significant regulatory effects on AMPK and its interaction signaling pathways.They exert their anti-colorectal cancer effects by inducing autophagy and apoptosis in colorectal cancer cells,promoting ferroptosis,inhibiting epithelial-mesenchymal transition,reversing drug resistance,and arresting the cell cycle.This article reviewed and summarized the relevant research on traditional Chinese medicine in the treatment of colorectal cancer in recent years,with a focus on the mechanism of traditional Chinese medicine in regulating the AMPK signaling pathway for the treatment of colorectal cancer.It is expected to provide ideas and references for the development of new drugs for clinical anti-colorectal cancer treatment.