肾上腺素不同给药途径治疗Ⅰ型超敏反应的研究进展OA

Epinephrine is the first-line drug for treating type I hypersensitivity reactions and can ef-fectively alleviate symptoms such as hypotension,erythema,urticaria,and angioedema,while also in-hibiting the further release of allergic mediators.In-tramuscular administration of epinephrine ensures rapid absorption and efficacy,and both epinephrine injection vials and auto-injectors are available on the market,providing timely treatment in emergen-cy situations.To enhance the convenience of drug administration and improve patient compliance,new routes of administration for epinephrine are being explored,including liquid nasal sprays,pow-der nasal sprays,sublingual formulations,and in-halers.This article summarizes the advantages and limitations of currently available and under-re-searched epinephrine formulations with different routes of administration and predicts future re-search directions and priorities.