PYCR1在肿瘤发生发展中的作用和机制研究进展OA

Pyrroline-5-carboxylate reductase 1(PYCR1)is a key enzyme in the proline biosynthesis pathway and has garnered widespread attention in the field of tumor research in recent years.Studies have shown that PYCR1 is abnormally expressed in a variety of malignant tumors.It plays a significant role in tumorigenesis and development by participating in metabolic reprogramming of tumor cells,regulating key signaling pathways,influencing the tumor microenvironment,and me-diating immune evasion,among other mechanisms.This article systematically reviews the biological structure and functions of PYCR1,its expression characteristics in various tumors,and the underlying molecular mechanisms.The focus is on exploring its role in promoting the occurrence and development of different tumors,as well as its involvement in mediating chemother-apy resistance.Additionally,the research progress and clinical application prospects of PYCR1 as a potential therapeutic target are analyzed,providing a theoretical basis and research directions for the development of novel anti-tumor strategies.