2017-2023年四川省儿童患者药品不良事件分析OA

Objective To analyze the characteristics of adverse drug events(ADEs)in pediatrics in Sichuan Prov-ince,and to provide evidence for the safety of clinical medication use in pediatrics.Methods The 57 098 adverse drug events of pediatric patients reported to the National Adverse Drug Reaction Monitoring Network by the institutions in Sichuan Province from 2017 to 2023 were retrieved,and EXCEL was used for retrospective analysis of demographic characteristics,medication in-formation,clinical manifestations,the impact on the original disease and prognosis.Results The age group with the highest number of reports was 3-6 years(14 142 cases,24.77%).The top 3 suspected drugs by total reported cases were antimicrobial agents(31 469 cases,50.80%),traditional Chinese medicine injections(7 287 cases,1.76%)and respiratory system drugs(5 496 cases,8.87%).For serious cases,the top 3 were antimicrobial agents(2 749 cases,39.51%),antineoplastic drugs(1 887 cases,27.12%),and psychotropic drugs(356 cases,5.12%).In pediatric ADEs,traditional Chinese medicine injec-tions account for a relatively high proportion of total cases but a low proportion of serious cases,whereas antineoplastic drugs show a low proportion of total cases but a relatively high proportion of serious cases.Among combination therapies,electrolytes,acid-base balance agents,and nutritional drugs ranked first(14 001/24 001,58.34%),primarily consisting of normal saline and glucose injections.Analysis of clinical manifestations showed that blood and lymphatic system disorders were more prevalent in se-rious reports than in total reports.Most cases had favorable outcomes(recovery rate:42.37%;improvement rate:54.93%),while severe ADEs had a recovery rate of 23.81%and an improvement rate of 65.60%.Conclusions Attention should be paid to medication safety risks across different pediatric age groups,with a particular focus on the use of antimicrobial and antineoplas-tic drugs.Enhanced monitoring of pediatric medication is recommended.