慢性萎缩性胃炎中医证型与血清SIRI、LRG1、G-17的相关性分析OA

Objective It is to explore the predictive diagnostic value of serum systemic inflammatory response index(SIRI),leucine-rich α2-glycoprotein 1(LRG1),and gastrin-17(G-17)for chronic atrophic gastritis(CAG),as well as their correlation with traditional Chinese medicine(TCM)types.Methods A total of 126 patients with CAG who visited the outpatient clinic,inpatient ward,and endoscopy center of the Third Affiliated Hospital of Beijing University of Chinese Medicine from March to December 2024 were selected as the atrophic group.Additionally,42 patients with chronic superfi-cial gastritis confirmed by gastroscopy during the same period were selected as the non-atrophic group.The information in-cluding gender,age,H.pylori infection status,data of the four diagnostic methods of TCM,laboratory test results,and endoscopic and pathological examination results of the patients were collected.The levels of SIRI,LRG1 and G-17 were compared between the two groups,the predictive diagnostic value of serum SIRI,LRG1,G-17 and their combination for CAG were analyzed by receiver operating characteristic(ROC)curve,the distributions of TCM syndrome types in the CAG patients were counted,and the levels of SIRI,LRG1,G-17 levels among CAG patients with different TCM types were com-pared,the relationship between TCM types and serum levels of SIRI,LRG1 and G-17 were analyzed by Pearson correlation analysis.Results There were statistically significant differences in gender and serum levels of SIRI,LRG1 and G-17 be-tween the atrophic and non-atrophic groups.The areas under the ROC curve(AUC)of serum SIRI,LRG1 and G-17 indi-vidually and their combination for predicting CAG were 0.7515,0.7262,0.7564 and 0.8662,respectively,the AUC of the combined prediction was higher than that of individual predictions(all P<0.05).The distributions of CAG syndrome types were as follows:spleen-stomach deficiency(33 cases)>spleen-stomach dampness-heat(32 cases)>liver-stomach Qi stagnation(26 cases)>liver-stomach stagnation heat(15 cases)>stomach collateral blood stasis(12 cases)>stomach Yin deficiency(8 cases).There were statistically significant differences in the levels of SIRI,LRG1 and G-17 among dif-ferent CAG TCM types(all P<0.05).Pearson correlation analysis showed that syndrome of spleen-stomach dampness-heat was positively correlated with SIRI,LRG1,and G-17(r=0.232,P<0.05;r=0.196,P<0.05;r=0.412,P<0.05),while syndrome of liver-stomach Qi stagnation was negatively correlated with LRG1(r=-0.271,P<0.05),syndrome of spleen-stomach deficiency and syndrome of stomach Yin deficiency were negatively correlated with G-17(r=-0.466,P<0.05;r=-0.233,P<0.05),syndrome of liver-stomach stagnation heat was positively correlated with G-17(r=0.216,P<0.05).Conclusion Serum levels of SIRI,LRG1 and G-17 have certain predictive diagnostic value for CAG and are correlated with TCM syndromes.