基于静电纺丝技术制备功能仿生支架研究进展OA

Tissue repair has always been a major challenge in the medical field.After the tissue of the human body is damaged,its self-regeneration ability is limited,and sometimes it cannot completely rely on its own recovery.Traditional repair materials(such as metal implants,polymer scaffolds,etc.)have limitations in biological activity and bionic structure,and cannot achieve good tissue integration and functional reconstruction.In recent years,electrospinning technology provides a method for the preparation of high-performance biomimetic scaffolds.Electrospun nanofiber scaffolds have high surface area,adjustable pore size and porosity,which can effectively simulate the expanded structure of human extracellular matrix and provide a good environment for cell adhesion,proliferation and differentiation.The scaffolds synthesized by electrospinning with natural polymers(such as polycaprolactone,gelatin,silk fibroin,etc.)have excellent biocompatibility and mechanical properties.In this paper,the research progress of electrospun biomimetic scaffolds is reviewed,and its future development is prospected.