铁死亡对糖尿病视网膜病变视网膜神经血管单元组成细胞调控机制的研究进展OA

Diabetic retinopathy(DR)is a common microvascular complication of diabetes,for which no definitive cure is currently available.Ferroptosis,a novel form of cell death characterized by iron dependency and lipid peroxidation,plays a prominent role in the retinal neurovascular unit.Emerging evidence indicates that ferroptosis affects the survival and func-tion of retinal endothelial cells,retinal pigment epithelial cells,pericytes,neurons,and glial cells,thereby contributing to hy-perglycemia-and aging-related retinal injury.Moreover,ferroptosis is closely associated with disruption of the blood-retinal barrier and retinal neurodegeneration.This review summarizes the molecular mechanisms of ferroptosis and its regulatory effects on the constituent cells of the retinal neurovascular unit in DR,providing a theoretical basis for the early diagnosis and intervention of DR.