铁死亡机制在糖尿病视网膜病变中的研究进展OA

Ferroptosis represents an iron-dependent form of programmed cell death,marked by the abnormal accumulation of lipid peroxides and a disruption in redox homeostasis.It has been demonstrated to participate in the pathological process of fundus and metabolic diseases.Consequently,exploring its molecular mechanisms has emerged as a hotspot in translational medicine research.Recent research has revealed a close link between the development of diabetic retinopathy(DR)and ferroptosis.The pathological procession of DR encompasses iron metabolism disorders,a breakdown of antioxidant system,and a cascade of lipid peroxidation.This paper offers a comprehensive review of the molecular association between ferroptosis and the development of DR.It also elucidates the trigger pathways of ferroptosis in retinal cells under high-glucose conditions.Further in-depth analysis indicates that ferroptosis establishes a positive feedback loop with mitochondrial dysfunction and inflammation.Through the oxidative stress-inflammation-angiogenesis axis,it exacerbates the destruction of blood-retinal barrier and causes damage to the neurovascular unit.Moreover,this paper delves into the translational potential of intervention strategies targeting ferroptosis.It proposes that future research should prioritize the screening of stage-specific biomarkers and the analysis of dynamic regulatory networks.The ultimate goal is to provide a novel direction for further exploring the pathogenesis and prevention of DR.